Chromatin provides both a means to accommodate a large amount of genetic material in a
small space and a means to package the same genetic material in different chromatin states …

The faithful maintenance of chromosome continuity in human cells during DNA replication
and repair is critical for preventing the conversion of normal diploid cells to an oncogenic …

Nearly all essential nuclear processes act on DNA packaged into arrays of nucleosomes.
However, our understanding of how these processes (for example, DNA replication, RNA …

▪ Abstract It has been a long-standing challenge to decipher the principles that enable cells
to both organize their genomes into compact chromatin and ensure that the genetic …

Histone lysine residues can be mono-, di-, or trimethylated. These posttranslational
modifications regulate the affinity of effector proteins and may also impact chromatin …

We present an analysis of over 1,100 of the∼ 10,000 predicted proteins encoded by the
genome sequence of the filamentous fungus Neurospora crassa. Seven major areas of …

Through epigenetic modifications, specific long-term phenotypic consequences can arise
from environmental influence on slowly evolving genomic DNA. Heritable epigenetic …

The PHD finger is a common structural motif found in all eukaryotic genomes. It is a Zn 2+-
binding domain and its closest structural relative is the RING domain. Many RING fingers …

Recent studies indicate that chromatin regulatory complexes produce biological specificity in
the way that letters produce meanings by combinations into words. Combinatorial assembly …

The mechanism by which the eukaryotic DNA-replication machinery penetrates condensed
chromatin structures to replicate the underlying DNA is poorly understood. Here we provide …