Mice remain the most studied animal model in pancreas research. Since the findings of this
research are typically extrapolated to humans, it is important to understand both similarities …

Type 2 diabetes mellitus (T2D) is a complex disease characterized by β-cell failure in the
setting of insulin resistance. The current evidence suggests that genetic predisposition, and …

Controversy exists regarding the potential regenerative influences of incretin therapy on
pancreatic β-cells versus possible adverse pancreatic proliferative effects. Examination of …

Context: Insulin resistance can be compensated by increased functional pancreatic β-cell
mass; otherwise, diabetes ensues. Such compensation depends not only on environmental …

The pancreas is an endoderm-derived glandular organ that participates in the regulation of
systemic glucose metabolism and food digestion through the function of its endocrine and …

This review focuses on the human pancreatic islet—including its structure, cell composition,
development, function, and dysfunction. After providing a historical timeline of key …

The prevalence of type 2 diabetes (T2D) and impaired glucose tolerance (IGT) increases
with ageing. T2D generally results from progressive impairment of the pancreatic islets to …

Context: Type 2 diabetes is characterized by a β-cell deficit and a progressive defect in β-
cell function. It has been proposed that the deficit in β-cells may be due to β-cell …

Pancreatic beta cells uniquely synthetize, store, and release insulin. Specific molecular,
functional as well as ultrastructural traits characterize their insulin secretion properties and …

Pancreas development in humans : Current Opinion in Endocrinology, Diabetes and Obesity
Pancreas development in humans : Current Opinion in Endocrinology, Diabetes and Obesity …