The epigenetics orchestra of Notch signaling: a symphony for cancer therapy
A Paniri, MM Hosseini, F Amjadi-Moheb… - …, 2023 - Taylor & Francis
The aberrant regulation of the Notch signaling pathway, which is a fundamental
developmental pathway, has been implicated in a wide range of human cancers. The Notch …
developmental pathway, has been implicated in a wide range of human cancers. The Notch …
Loss of function of canonical Notch signaling drives head and neck carcinogenesis
PE Nyman, D Buehler, PF Lambert - Clinical Cancer Research, 2018 - AACR
Purpose: Head and neck squamous cell carcinoma (HNSCC), a common cancer worldwide,
is etiologically associated with tobacco use, high alcohol consumption, and high-risk human …
is etiologically associated with tobacco use, high alcohol consumption, and high-risk human …
Integrated analysis of whole-genome ChIP-Seq and RNA-Seq data of primary head and neck tumor samples associates HPV integration sites with open chromatin …
Chromatin alterations mediate mutations and gene expression changes in cancer.
Chromatin immunoprecipitation followed by sequencing (ChIP-Seq) has been utilized to …
Chromatin immunoprecipitation followed by sequencing (ChIP-Seq) has been utilized to …
Distinct molecular etiologies of male and female hepatocellular carcinoma
Background Sex-differences in cancer occurrence and mortality are evident across tumor
types; men exhibit higher rates of incidence and often poorer responses to treatment …
types; men exhibit higher rates of incidence and often poorer responses to treatment …
Epigenomic dysregulation-mediated alterations of key biological pathways and tumor immune evasion are hallmarks of gingivo-buccal oral cancer
Background Gingivo-buccal oral squamous cell carcinoma (OSCC-GB) is the most common
cancer among men in India and is associated with high mortality. Although OSCC-GB is …
cancer among men in India and is associated with high mortality. Although OSCC-GB is …
Discovery and development of differentially methylated regions in human papillomavirus‐related oropharyngeal squamous cell carcinoma
Human papillomavirus (HPV)‐related oropharyngeal squamous cell carcinoma (OPSCC)
exhibits a different composition of epigenetic alterations. In this study, we identified …
exhibits a different composition of epigenetic alterations. In this study, we identified …
S-adenosylmethionine treatment of colorectal cancer cell lines alters DNA methylation, DNA repair and tumor progression-related gene expression
S Zsigrai, A Kalmár, ZB Nagy, BK Barták, G Valcz… - Cells, 2020 - mdpi.com
Global DNA hypomethylation is a characteristic feature of colorectal carcinoma (CRC). The
tumor inhibitory effect of S-adenosylmethionine (SAM) methyl donor has been described in …
tumor inhibitory effect of S-adenosylmethionine (SAM) methyl donor has been described in …
[HTML][HTML] The associations between Deltex1 and clinical characteristics of breast cancer
X Liu, Y Xian, H Xu, M Hu, K Che, X Liu, H Wang - Gland surgery, 2021 - ncbi.nlm.nih.gov
Background Deltex 1 (DTX1) is a single transmembrane protein with ubiquitin E3 ligase
activity which has been found to play a role in the development of several cancers. We …
activity which has been found to play a role in the development of several cancers. We …
[HTML][HTML] Downregulation of CEACAM6 gene expression in laryngeal squamous cell carcinoma is an effect of DNA hypermethylation and correlates with disease …
K Bednarek, M Kostrzewska-Poczekaj… - American journal of …, 2018 - ncbi.nlm.nih.gov
We have turned our attention to CEACAM6 gene, already described as deregulated in
various types of cancer. By using the expression microarrays performed on the set of 16 …
various types of cancer. By using the expression microarrays performed on the set of 16 …
HEY1 is expressed independent of NOTCH1 and is associated with poor prognosis in head and neck squamous cell carcinoma
Objectives Notch signaling is frequently altered in head and neck squamous cell carcinoma
(HNSCC). However, the nature and clinical implications of this dysregulation are not well …
(HNSCC). However, the nature and clinical implications of this dysregulation are not well …