The epigenetics orchestra of Notch signaling: a symphony for cancer therapy

A Paniri, MM Hosseini, F Amjadi-Moheb… - …, 2023 - Taylor & Francis
The aberrant regulation of the Notch signaling pathway, which is a fundamental
developmental pathway, has been implicated in a wide range of human cancers. The Notch …

Loss of function of canonical Notch signaling drives head and neck carcinogenesis

PE Nyman, D Buehler, PF Lambert - Clinical Cancer Research, 2018 - AACR
Purpose: Head and neck squamous cell carcinoma (HNSCC), a common cancer worldwide,
is etiologically associated with tobacco use, high alcohol consumption, and high-risk human …

Integrated analysis of whole-genome ChIP-Seq and RNA-Seq data of primary head and neck tumor samples associates HPV integration sites with open chromatin …

DZ Kelley, EL Flam, E Izumchenko, LV Danilova… - Cancer research, 2017 - AACR
Chromatin alterations mediate mutations and gene expression changes in cancer.
Chromatin immunoprecipitation followed by sequencing (ChIP-Seq) has been utilized to …

Distinct molecular etiologies of male and female hepatocellular carcinoma

HM Natri, MA Wilson, KH Buetow - BMC cancer, 2019 - Springer
Background Sex-differences in cancer occurrence and mortality are evident across tumor
types; men exhibit higher rates of incidence and often poorer responses to treatment …

Epigenomic dysregulation-mediated alterations of key biological pathways and tumor immune evasion are hallmarks of gingivo-buccal oral cancer

D Das, S Ghosh, A Maitra, NK Biswas, CK Panda… - Clinical …, 2019 - Springer
Background Gingivo-buccal oral squamous cell carcinoma (OSCC-GB) is the most common
cancer among men in India and is associated with high mortality. Although OSCC-GB is …

Discovery and development of differentially methylated regions in human papillomavirus‐related oropharyngeal squamous cell carcinoma

S Ren, D Gaykalova, J Wang, T Guo… - … journal of cancer, 2018 - Wiley Online Library
Human papillomavirus (HPV)‐related oropharyngeal squamous cell carcinoma (OPSCC)
exhibits a different composition of epigenetic alterations. In this study, we identified …

S-adenosylmethionine treatment of colorectal cancer cell lines alters DNA methylation, DNA repair and tumor progression-related gene expression

S Zsigrai, A Kalmár, ZB Nagy, BK Barták, G Valcz… - Cells, 2020 - mdpi.com
Global DNA hypomethylation is a characteristic feature of colorectal carcinoma (CRC). The
tumor inhibitory effect of S-adenosylmethionine (SAM) methyl donor has been described in …

[HTML][HTML] The associations between Deltex1 and clinical characteristics of breast cancer

X Liu, Y Xian, H Xu, M Hu, K Che, X Liu, H Wang - Gland surgery, 2021 - ncbi.nlm.nih.gov
Background Deltex 1 (DTX1) is a single transmembrane protein with ubiquitin E3 ligase
activity which has been found to play a role in the development of several cancers. We …

[HTML][HTML] Downregulation of CEACAM6 gene expression in laryngeal squamous cell carcinoma is an effect of DNA hypermethylation and correlates with disease …

K Bednarek, M Kostrzewska-Poczekaj… - American journal of …, 2018 - ncbi.nlm.nih.gov
We have turned our attention to CEACAM6 gene, already described as deregulated in
various types of cancer. By using the expression microarrays performed on the set of 16 …

HEY1 is expressed independent of NOTCH1 and is associated with poor prognosis in head and neck squamous cell carcinoma

EM Rettig, JA Bishop, N Agrawal, CH Chung… - Oral Oncology, 2018 - Elsevier
Objectives Notch signaling is frequently altered in head and neck squamous cell carcinoma
(HNSCC). However, the nature and clinical implications of this dysregulation are not well …