A large amount of evidence has demonstrated the power of exercise to support cognitive
function, the effects of which can last for considerable time. An emerging line of scientific …

Epigenetics is a quickly growing field encompassing mechanisms regulating gene
expression that do not involve changes in the genotype. Epigenetics is of increasing …

Small non-coding RNAs (sncRNAs) are potential vectors at the interface between genes and
environment. We found that traumatic stress in early life altered mouse microRNA (miRNA) …

Long-lasting memories require specific gene expression programmes that are, in part,
orchestrated by epigenetic mechanisms. Of the epigenetic modifications identified in …

Cognitive decline is a debilitating feature of most neurodegenerative diseases of the central
nervous system, including Alzheimer's disease. The causes leading to such impairment are …

Although the critical role for epigenetic mechanisms in development and cell differentiation
has long been appreciated, recent evidence reveals that these mechanisms are also …

Understanding the underlying mechanisms of memory formation and maintenance has been
a major goal in the field of neuroscience. Memory formation and maintenance are tightly …

Epigenetic mechanisms, which include DNA methylation, a variety of post-translational
modifications of histone proteins (acetylation, phosphorylation, methylation, ubiquitination …

Understanding the cellular and molecular mechanisms underlying the formation and
maintenance of memories is a central goal of the neuroscience community. It is well …

Protein Ser/Thr phosphatase-1 (PP1) catalyzes the majority of eukaryotic protein
dephosphorylation reactions in a highly regulated and selective manner. Recent studies …