N‐acetylcysteine: a review of clinical usefulness (an old drug with new tricks)
GK Schwalfenberg - Journal of nutrition and metabolism, 2021 - Wiley Online Library
Objective. To review the clinical usefulness of N‐acetylcysteine (NAC) as treatment or
adjunctive therapy in a number of medical conditions. Use in Tylenol overdose, cystic …
adjunctive therapy in a number of medical conditions. Use in Tylenol overdose, cystic …
The role of neuroimmune signaling in alcoholism
Alcohol consumption and stress increase brain levels of known innate immune signaling
molecules. Microglia, the innate immune cells of the brain, and neurons respond to alcohol …
molecules. Microglia, the innate immune cells of the brain, and neurons respond to alcohol …
Neural and psychological mechanisms underlying compulsive drug seeking habits and drug memories–indications for novel treatments of addiction
BJ Everitt - European Journal of Neuroscience, 2014 - Wiley Online Library
This review discusses the evidence for the hypothesis that the development of drug
addiction can be understood in terms of interactions between Pavlovian and instrumental …
addiction can be understood in terms of interactions between Pavlovian and instrumental …
Cocaine-induced adaptations in D1 and D2 accumbens projection neurons (a dichotomy not necessarily synonymous with direct and indirect pathways)
Cocaine exposure causes enduring neuroadaptations in ventral striatum, or nucleus
accumbens (NAc), an area critically involved in reward learning and relapse of drug …
accumbens (NAc), an area critically involved in reward learning and relapse of drug …
Induction of innate immune genes in brain create the neurobiology of addiction
FT Crews, J Zou, L Qin - Brain, behavior, and immunity, 2011 - Elsevier
Addiction occurs through repeated abuse of drugs that progressively reduce behavioral
control and cognitive flexibility while increasing limbic negative emotion. Recent discoveries …
control and cognitive flexibility while increasing limbic negative emotion. Recent discoveries …
Neurocircuitry of alcohol addiction: synthesis from animal models
GF Koob - Handbook of clinical neurology, 2014 - Elsevier
Alcoholism, more generically drug addiction, can be defined as a chronically relapsing
disorder characterized by:(1) compulsion to seek and take the drug (alcohol);(2) loss of …
disorder characterized by:(1) compulsion to seek and take the drug (alcohol);(2) loss of …
Astrocyte regulation of synaptic signaling in psychiatric disorders
Over the last 15 years, the field of neuroscience has evolved toward recognizing the critical
role of astroglia in shaping neuronal synaptic activity and along with the pre-and …
role of astroglia in shaping neuronal synaptic activity and along with the pre-and …
Gq-DREADD selectively initiates glial glutamate release and inhibits cue-induced cocaine seeking
Background Glial cells of the central nervous system directly influence neuronal activity by
releasing neuroactive small molecules, including glutamate. Long-lasting cocaine-induced …
releasing neuroactive small molecules, including glutamate. Long-lasting cocaine-induced …
Pain and suicidality: insights from reward and addiction neuroscience
I Elman, D Borsook, ND Volkow - Progress in neurobiology, 2013 - Elsevier
Suicidality is exceedingly prevalent in pain patients. Although the pathophysiology of this
link remains unclear, it may be potentially related to the partial congruence of physical and …
link remains unclear, it may be potentially related to the partial congruence of physical and …
[HTML][HTML] Toll-like receptor signaling and stages of addiction
Abstract Background Athina Markou and her colleagues discovered persistent changes in
adult behavior following adolescent exposure to ethanol or nicotine consistent with …
adult behavior following adolescent exposure to ethanol or nicotine consistent with …