Cognitive ageing research examines the cognitive abilities that are preserved and/or those
that decline with advanced age. There is great individual variability in cognitive ageing …

Recent advancements in computational approaches and neuroimaging techniques have
refined our understanding of the precuneus. While previously believed to be largely a visual …

Alzheimer's disease (AD) is a progressive neurodegenerative disorder leading to loss of
cognitive abilities and ultimately, death. With no cure available, limited treatments mostly …

The function of neural circuits and networks can be controlled, in part, by modulating the
synchrony of their components' activities. Network hypersynchrony and altered oscillatory …

The global prevalence of dementia is as high as 24 million, and has been predicted to
quadruple by the year 2050. In the US alone, Alzheimer disease (AD)–the most frequent …

As the field begins to test the concept of a" preclinical" stage of neurodegenerative disease,
when the pathophysiological process has begun in the brain, but clinical symptoms are not …

Alzheimer's disease causes a progressive dementia that currently affects over 35 million
individuals worldwide and is expected to affect 115 million by 2050 (ref. 1). There are no …

Loss of memory is among the first symptoms reported by patients suffering from Alzheimer's
disease (AD) and by their caretakers. Working memory and long-term declarative memory …

There is an increasing role for biological markers (biomarkers) in the understanding and
diagnosis of neurodegenerative disorders. The application of imaging biomarkers …

Elevated hippocampal activation is observed in conditions that confer risk for Alzheimer's
disease, including amnestic mild cognitive impairment (aMCI). Studies in relevant animal …