Opportunities for Therapeutic Modulation of O-GlcNAc

SS Cheng, AC Mody, CM Woo - Chemical Reviews, 2024 - ACS Publications
O-Linked β-N-acetylglucosamine (O-GlcNAc) is an essential, dynamic monosaccharide post-
translational modification (PTM) found on serine and threonine residues of thousands of …

The Emerging Role of Galectins and O-GlcNAc Homeostasis in Processes of Cellular Differentiation

R Tazhitdinova, AV Timoshenko - Cells, 2020 - mdpi.com
Galectins are a family of soluble β-galactoside-binding proteins with diverse glycan-
dependent and glycan-independent functions outside and inside the cell. Human cells …

Hexosamine biosynthetic pathway-derived O-GlcNAcylation is critical for RANKL-mediated osteoclast differentiation

MJ Kim, HS Kim, S Lee, KY Min, WS Choi… - International Journal of …, 2021 - mdpi.com
O-linked-N-acetylglucosaminylation (O-GlcNAcylation) performed by O-GlcNAc transferase
(OGT) is a nutrient-responsive post-translational modification (PTM) via the hexosamine …

O-linked N-acetylglucosamine affects mitochondrial homeostasis by regulating Parkin-dependent mitophagy in hyperoxia-injured alveolar type II cells injury

Y Xuefei, L Dongyan, L Tianming, Z Hejuan… - Respiratory …, 2023 - Springer
Background The level of linked N-acetylglucosamine (O-GlcNAc) has been proved to be a
sensor of cell state, but its relationship with hyperoxia-induced alveolar type 2 epithelial cells …

O-GlcNAc-Mediated Regulation of Galectin Expression and Secretion in Human Promyelocytic HL-60 Cells Undergoing Neutrophilic Differentiation

A McTague, R Tazhitdinova, AV Timoshenko - Biomolecules, 2022 - mdpi.com
In this study, we have tested the hypothesis that the expression and secretion of galectins
are driven through mechanisms globally impacted by homeostatic regulation involving the …

Protein O‐GlcNAcylation: The sweet hub in liver metabolic flexibility from a (patho)physiological perspective

YJ Hu, X Zhang, HM Lv, Y Liu, SZ Li - Liver International, 2024 - Wiley Online Library
O‐GlcNAcylation is a dynamic, reversible and atypical O‐glycosylation that regulates
various cellular physiological processes via conformation, stabilisation, localisation …

Protein O-GlcNAcylation promotes trophoblast differentiation at implantation

PT Ruane, CMJ Tan, DJ Adlam, SJ Kimber, DR Brison… - Cells, 2020 - mdpi.com
Embryo implantation begins with blastocyst trophectoderm (TE) attachment to the
endometrial epithelium, followed by the breaching of this barrier by TE-derived trophoblast …