Bioorthogonal chemistry represents a class of high-yielding chemical reactions that proceed
rapidly and selectively in biological environments without side reactions towards …

The emerging inverse electron demand Diels–Alder (IEDDA) reaction stands out from other
bioorthogonal reactions by virtue of its unmatchable kinetics, excellent orthogonality and …

A nearly forgotten reaction discovered more than 60 years ago—the cycloaddition of a cyclic
alkyne and an organic azide, leading to an aromatic triazole—enjoys a remarkable …

Bioorthogonal cycloaddition reactions between tetrazines and strained dienophiles are
widely used for protein, lipid and glycan labelling because of their extremely rapid kinetics …

Driven by the ever-increasing pace of drug discovery and the need to push the boundaries
of unexplored chemical space, medicinal chemists are routinely turning to unusual strained …

Bioorthogonal chemistries can be used to tag diverse classes of biomolecules in cells and
other complex environments. With over 20 unique transformations now available, though …

The use of covalent chemistry to track biomolecules in their native environment—a focus of
bioorthogonal chemistry—has received considerable interest recently among chemical …

The surging development of bioorthogonal chemistry has profoundly transformed chemical
biology over the last two decades. Involving chemical partners that specifically react together …

There is growing interest in the use of inverse Diels–Alder tetrazine cycloadditions as rapid
catalyst-free bioorthogonal reactions.[1–3] Fluorogenic tetrazines that increase in …

Bioorthogonal chemistry has enabled the selective labeling and detection of biomolecules in
living systems. Bioorthogonal smart probes, which become fluorescent or deliver imaging or …