Store-operated calcium channels: from function to structure and back again
RS Lewis - Cold Spring Harbor perspectives in biology, 2020 - cshperspectives.cshlp.org
Store-operated calcium (Ca2+) entry (SOCE) occurs through a widely distributed family of
ion channels activated by the loss of Ca2+ from the endoplasmic reticulum (ER). The best …
ion channels activated by the loss of Ca2+ from the endoplasmic reticulum (ER). The best …
[HTML][HTML] STIM1 activation of Orai1
V Lunz, C Romanin, I Frischauf - Cell calcium, 2019 - Elsevier
Abstract A primary calcium (Ca 2+) entry pathway into non-excitable cells is through the
store-operated Ca 2+ release activated Ca 2+(CRAC) channel. Ca 2+ entry into cells is …
store-operated Ca 2+ release activated Ca 2+(CRAC) channel. Ca 2+ entry into cells is …
An apical Phe-His pair defines the Orai1-coupling site and its occlusion within STIM1
Ca2+ signal-generation through inter-membrane junctional coupling between endoplasmic
reticulum (ER) STIM proteins and plasma membrane (PM) Orai channels, remains a vital but …
reticulum (ER) STIM proteins and plasma membrane (PM) Orai channels, remains a vital but …
The Orai1 Store-Operated Calcium Channel Functions as a Hexamer*♦
Orai channels mediate store-operated Ca 2+ signals crucial in regulating transcription in
many cell types, and implicated in numerous immunological and inflammatory disorders …
many cell types, and implicated in numerous immunological and inflammatory disorders …
STIM1-dependent peripheral coupling governs the contractility of vascular smooth muscle cells
Peripheral coupling between the sarcoplasmic reticulum (SR) and plasma membrane (PM)
forms signaling complexes that regulate the membrane potential and contractility of vascular …
forms signaling complexes that regulate the membrane potential and contractility of vascular …
Molecular mechanisms of STIM/Orai communication
Ca2+ entry into the cell via store-operated Ca2+ release-activated Ca2+ (CRAC) channels
triggers diverse signaling cascades that affect cellular processes like cell growth, gene …
triggers diverse signaling cascades that affect cellular processes like cell growth, gene …
Mitochondria control store‐operated Ca2+ entry through Na+ and redox signals
Mitochondria exert important control over plasma membrane (PM) Orai1 channels mediating
store‐operated Ca2+ entry (SOCE). Although the sensing of endoplasmic reticulum (ER) …
store‐operated Ca2+ entry (SOCE). Although the sensing of endoplasmic reticulum (ER) …
The STIM1-binding site nexus remotely controls Orai1 channel gating
Abstract The ubiquitously expressed Orai Ca2+ channels are gated through a unique
process of intermembrane coupling with the Ca2+-sensing STIM proteins. Despite the …
process of intermembrane coupling with the Ca2+-sensing STIM proteins. Despite the …
Activation mechanisms and structural dynamics of STIM proteins
M Sallinger, H Grabmayr, C Humer… - The Journal of …, 2024 - Wiley Online Library
The family of stromal interaction molecules (STIM) includes two widely expressed single‐
pass endoplasmic reticulum (ER) transmembrane proteins and additional splice variants …
pass endoplasmic reticulum (ER) transmembrane proteins and additional splice variants …
STIM proteins: an ever-expanding family
Stromal interaction molecules (STIM) are a distinct class of ubiquitously expressed single-
pass transmembrane proteins in the endoplasmic reticulum (ER) membrane. Together with …
pass transmembrane proteins in the endoplasmic reticulum (ER) membrane. Together with …