The immunosuppressive status of the tumor microenvironment (TME) remains poorly
defined due to a lack of understanding regarding the function of tumor-associated …

Tumor-associated macrophages (TAMs) constitute a plastic and heterogeneous cell
population of the tumor microenvironment (TME) that can account for up to 50% of some …

Epithelial–mesenchymal transition (EMT) has been shown to play a critical role in tumor
development from initiation to metastasis. EMT could be regarded as a continuum, with …

Abstract Hypoxia‐inducible factor 1 (HIF‐1) plays an indispensable role in the hypoxic tumor
microenvironment. Hypoxia and HIF‐1 are involved in multiple aspects of tumor progression …

Rates of obesity and diabetes have increased significantly over the past decades and the
prevalence is expected to continue to rise further in the coming years. Many observations …

Hepatocellular carcinoma (HCC) ranks the most common primary liver malignancy and the
third leading cause of tumor-related mortality worldwide. Unfortunately, despite advances in …

Cancer is a complex disease whose outcome depends largely on the cross-talk between the
tumor and its microenvironment. Here, we review the evolution of the field of tumor …

Tumor-associated macrophages (TAMs) are some of the most abundant immune cells within
tumors and perform a broad repertoire of functions via diverse phenotypes. On the basis of …

Hepatocellular carcinoma (HCC) is a morbid condition for which surgical and ablative
therapy are the only options for cure. Nonetheless, over half of patients treated with an R0 …

Tumor-associated macrophages are a major constituent of malignant tumors and are known
to stimulate key steps in tumor progression. In our review in this journal in 2006, we …