In response to mechanical forces and the aging process, bone in the adult skeleton is
continuously remodeled by a process in which old and damaged bone is removed by bone …

Cardiac fibrosis plays an indispensable role in cardiac tissue homeostasis and repair after
myocardial infarction (MI). The cardiac fibroblast-to-myofibroblast differentiation and …

Fibrotic scars appear after spinal cord injury (SCI) and are mainly composed of fibroblasts
and excess extracellular matrix (ECM), including different types of collagen. The temporal …

Biologics are revolutionizing the treatment of chronic diseases, such as cancer and
monogenic disorders, by overcoming the limits of classic therapeutic approaches using …

Oxidative stress is the central cause of angiotensin II (Ang II)-induced myocardial injury, and
nuclear factor erythroid 2-related factor (Nrf2) is the core molecule of the anti-oxidant …

Zebrafish have a lifelong cardiac regenerative ability after damage, whereas mammals lose
this capacity during early postnatal development. This study investigated whether the …

Therapeutic angiogenesis aims at promoting the growth of blood vessels to restore
perfusion in ischemic tissues or aid tissue regeneration. Vascular endothelial growth factor …

Abstract BMP-1/tolloid-like proteinases (BTPs) are major players in tissue morphogenesis,
growth and repair. They act by promoting the deposition of structural extracellular matrix …

Previous studies have demonstrated that bone morphogenetic proteins (BMPs) play
important roles in cardiovascular diseases, including atherosclerosis, artery calcification …

Obesity strongly increases the risk of cardiometabolic diseases, yet the underlying mediators
of this relationship are not fully understood. Given that obesity has broad effects on …