The balance between oxidation and antioxidant is crucial for maintaining homeostasis. Once
disrupted, it can lead to various pathological outcomes and diseases, such as depression …

Despite the progress that has occurred in recent years in the development of therapies to
treat painful and inflammatory diseases, there is still a need for effective and potent …

Patients with chronic neuropathic pain frequently suffer from symptoms of anhedonia, which
is a core symptom of depression. Accumulating studies suggest that gut microbiota may play …

The transcription factor erythroid 2-related factor 2 (Nrf2) and brain-derived neurotrophic
factor (BDNF) play a key role in depression. However, the molecular mechanisms …

Depression is one of the most common mood disorders with a high rate of relapse.
Accumulating evidence suggests that the transcription factor Kelch-like erythroid cell-derived …

Oxidative stress, resulting from an imbalance between the formation of damaging free
radicals and availability of protective antioxidants, can contribute to peripheral neuropathic …

Mounting evidence suggests the impact of maternal diet on the health of offspring. We
reported that maternal diet of sulforaphane glucosinolate (SGS) could prevent behavioral …

Background Neuropathic pain is a multifaceted and ubiquitous disease across the globe.
Mood disorders, such as anxiety and depression, are frequently observed in patients …

Background Patients suffering from chronic pain often also exhibit depression symptoms.
Soluble epoxide hydrolase (sEH) inhibitors can decrease blood levels of inflammatory …

Background Xiaoyaosan (XYS), a traditional Chinese medicine formulation, has been used
in the treatment of depression. However, no studies have yet identified the active …