Aging is driven by hallmarks fulfilling the following three premises:(1) their age-associated
manifestation,(2) the acceleration of aging by experimentally accentuating them, and (3) the …

Acetyl-CoA is a metabolite at the crossroads of central metabolism and the substrate of
histone acetyltransferases regulating gene expression. In many tissues fasting or lifespan …

Caloric restriction and intermittent fasting prolong the lifespan and healthspan of model
organisms and improve human health. The natural polyamine spermidine has been similarly …

Aging is a physiological decline in both structural homeostasis and functional integrity,
progressively affecting organismal health. A major hallmark of aging is the accumulation of …

Epigenetic alterations pose one major hallmark of organismal aging. Here, we provide an
overview on recent findings describing the epigenetic changes that arise during aging and …

Historical and demographical human cohorts of populations exposed to famine, as well as
animal studies, revealed that exposure to food deprivation is associated to lasting health …

It has been four years since long COVID—the protracted consequences that survivors of
COVID-19 face—was first described. Yet, this entity continues to devastate the quality of life …

SARS-CoV-2 non-structural protein Nsp14 is a highly conserved enzyme necessary for viral
replication. Nsp14 forms a stable complex with non-structural protein Nsp10 and exhibits …

Abstract p300/CBP histone acetyltransferases (HAT) are critical transcription coactivators
involved in multiple cellular activities. They act at multiple levels in non-small cell lung …

Atrial fibrosis induced by aging is one of the main causes of atrial fibrillation (AF), but the
potential molecular mechanism is not clear. Acetyltransferase p300 participates in the …