The ocular tissue microenvironment is immune-privileged and uses multiple
immunosuppressive mechanisms to prevent the induction of inflammation. The retinal …

The outer blood-retina barrier (oBRB), crucial for the survival and the proper functioning of
the overlying retinal layers, is disrupted in numerous diseases affecting the retina, leading to …

Recent trials of retinal pigment epithelium (RPE) transplantation for the treatment of
disorders such as age-related macular degeneration have been promising. However …

Human embryonic stem cell-derived retinal pigment epithelial (hESC-RPE) cells could serve
as a replacement therapy in advanced stages of age-related macular degeneration …

Background: The development and use of human embryonic stem cells (hESCs) in
regenerative medicine have been revolutionary, offering significant advancements in …

Replacement of dysfunctional retinal pigmented epithelium (RPE) with grafts derived from
stem cells has the potential to improve vision for patients with retinal disorders. In fact, the …

Background Human pluripotent stem cells (hPSCs) provide a promising cell source for
retinal cell replacement therapy but often lack standardized cell production and live-cell …

Background Transplantation of human pluripotent stem cell-derived retinal pigment
epithelium (RPE) is an urgently needed treatment for the cure of degenerative diseases of …

Age-related macular degeneration is an incurable chronic neurodegenerative disease,
causing progressive loss of the central vision and even blindness. Up-to-date therapeutic …

AIM To explore an xeno-free and defined coating substrate suitable for the culture of H9
human embryonic stem cell-derived retinal pigment epithelial (hES-RPE) cells in vitro, and …