Oleanolic acid: extraction, characterization and biological activity

JM Castellano, S Ramos-Romero, JS Perona - Nutrients, 2022 - mdpi.com
Oleanolic acid, a pentacyclic triterpenoid ubiquitously present in the plant kingdom, is
receiving outstanding attention from the scientific community due to its biological activity …

Betulin and its derivatives as novel compounds with different pharmacological effects

S Amiri, S Dastghaib, M Ahmadi, P Mehrbod… - Biotechnology …, 2020 - Elsevier
Betulin (B) and Betulinic acid (BA) are natural pentacyclic lupane-structure triterpenoids
which possess a wide range of pharmacological activities. Recent evidence indicates that B …

Pharmacological properties, molecular mechanisms, and pharmaceutical development of asiatic acid: a pentacyclic triterpenoid of therapeutic promise

MF Nagoor Meeran, SN Goyal, K Suchal… - Frontiers in …, 2018 - frontiersin.org
Asiatic acid (AA) is a naturally occurring aglycone of ursane type pentacyclic triterpenoids. It
is abundantly present in many edible and medicinal plants including Centella asiatica that is …

New pharmacological opportunities for betulinic acid

JL Ríos, S Máñez - Planta medica, 2018 - thieme-connect.com
Betulinic acid is a naturally occurring pentacyclic lupane-type triterpenoid usually isolated
from birch trees, but present in many other botanical sources. It is found in different plant …

Synthesis, biology and clinical significance of pentacyclic triterpenes: a multi-target approach to prevention and treatment of metabolic and vascular diseases

H Sheng, H Sun - Natural product reports, 2011 - pubs.rsc.org
Covering: up to May 2010 This review (with 335 references cited) is devoted to pentacyclic
triterpenes. The total synthesis, semi-synthesis, structural modification, and metabolic …

The pentacyclic triterpenoids in herbal medicines and their pharmacological activities in diabetes and diabetic complications

A Alqahtani, K Hamid, A Kam, KH Wong… - Current Medicinal …, 2013 - ingentaconnect.com
Pentacyclic triterpenoids including the oleanane, ursane and lupane groups are widely
distributed in many medicinal plants, such as Glycyrrhiza species, Gymnema species …

Biochemical basis of the antidiabetic activity of oleanolic acid and related pentacyclic triterpenes

JM Castellano, A Guinda, T Delgado, M Rada… - Diabetes, 2013 - Am Diabetes Assoc
Oleanolic acid (OA), a natural component of many plant food and medicinal herbs, is
endowed with a wide range of pharmacological properties whose therapeutic potential has …

Oleanolic, ursolic, and betulinic acids as food supplements or pharmaceutical agents for type 2 diabetes: promise or illusion?

FSG Silva, PJ Oliveira, MF Duarte - Journal of agricultural and …, 2016 - ACS Publications
Oleanolic (OA), ursolic (UA), and betulinic (BA) acids are three triterpenic acids (TAs) with
potential effects for treatment of type 2 diabetes (T2DM). Mechanistic studies showed that …

Ursolic acid derivatives for pharmaceutical use: a patent review (2012-2016)

H Hussain, IR Green, I Ali, IA Khan, Z Ali… - Expert Opinion on …, 2017 - Taylor & Francis
ABSTRACT Introduction: Ursolic acid (UA), belongs to a group of pentacyclic triterpenoids
and is known to possess some very interesting biological properties. Protocols have been …

Maslinic acid, a natural phytoalexin-type triterpene from olives—a promising nutraceutical?

G Lozano-Mena, M Sánchez-González, ME Juan… - Molecules, 2014 - mdpi.com
Maslinic acid is a pentacyclic triterpene found in a variety of natural sources, ranging from
herbal remedies used in traditional Asian medicine to edible vegetables and fruits present in …