The concept of differentiation therapy emerged from the fact that hormones or cytokines may
promote differentiation ex vivo, thereby irreversibly changing the phenotype of cancer cells …

Although acute promyelocytic leukemia (APL) is one of the most characterized forms of
acute myeloid leukemia (AML), the molecular mechanisms involved in the development and …

Acute myeloid leukemia (AML) is an extremely heterogeneous disease defined by the clonal
growth of myeloblasts/promyelocytes not only in the bone marrow but also in peripheral …

The transformation of acute promyelocytic leukemia (APL) from an often fatal to highly
curable cancer with long-term survival exceeding 90% is one of the greatest and most …

Most acute promyelocytic leukemia (APL) are caused by PML-RARA, a translocation-driven
fusion oncoprotein discovered three decades ago. Over the years, several other types of …

Acute promyelocytic leukemia (APL) is associated with a severe coagulopathy leading to
rapid morbidity and mortality if left untreated. The definitive diagnosis of APL is made by …

The first decade of capture‐based targeted whole exome sequencing (WES) has now
passed, while the sequencing modality continues to find more widespread usage in clinical …

Retinoic acid (RA) and arsenic target the t (15; 17)(q24; q21) PML/RARA driver of acute
promyelocytic leukemia (APL), their combination now curing over 95% patients. We report …

Despite the high probability of cure of patients with acute promyelocytic leukemia (APL),
mechanisms of relapse are still largely unclear. Mutational profiling at diagnosis and/or …

A hallmark of acute promyelocytic leukemia (APL) is altered nuclear architecture, with
disruption of promyelocytic leukemia (PML) nuclear bodies (NBs) mediated by the PML …