Cytokines in inflammatory disease

S Kany, JT Vollrath, B Relja - International journal of molecular sciences, 2019 - mdpi.com
This review aims to briefly discuss a short list of a broad variety of inflammatory cytokines.
Numerous studies have implicated that inflammatory cytokines exert important effects with …

Apoptosis, autophagy, NETosis, necroptosis, and pyroptosis mediated programmed cell death as targets for innovative therapy in rheumatoid arthritis

J Zhao, P Jiang, S Guo, SJ Schrodi, D He - Frontiers in immunology, 2021 - frontiersin.org
Rheumatoid arthritis (RA) is a chronic inflammatory joint disease that can lead to clinical
manifestations of systemic diseases. Its leading features include chronic synovial …

Age and age-related diseases: role of inflammation triggers and cytokines

IM Rea, DS Gibson, V McGilligan… - Frontiers in …, 2018 - frontiersin.org
Cytokine dysregulation is believed to play a key role in the remodeling of the immune
system at older age, with evidence pointing to an inability to fine-control systemic …

[HTML][HTML] Role of the NLRP3 inflammasome in autoimmune diseases

Z Li, J Guo, L Bi - Biomedicine & pharmacotherapy, 2020 - Elsevier
NOD-like receptor family pyrin domain containing 3 (NLRP3) is an intracellular receptor that
senses foreign pathogens and endogenous danger signals. It assembles with apoptosis …

Focus on the Role of NLRP3 Inflammasome in Diseases

R Fusco, R Siracusa, T Genovese… - International journal of …, 2020 - mdpi.com
Inflammation is a protective reaction activated in response to detrimental stimuli, such as
dead cells, irritants or pathogens, by the evolutionarily conserved immune system and is …

Crosstalk between gut microbiota and innate immunity and its implication in autoimmune diseases

Y Jiao, L Wu, ND Huntington, X Zhang - Frontiers in immunology, 2020 - frontiersin.org
The emerging concept of microbiota contributing to local mucosal homeostasis has fueled
investigation into its specific role in immunology. Gut microbiota is mostly responsible for …

[HTML][HTML] Innate immunity drives pathogenesis of rheumatoid arthritis

MI Edilova, A Akram, AA Abdul-Sater - Biomedical Journal, 2021 - Elsevier
Rheumatoid arthritis (RA) is an autoimmune disease affecting∼ 1% of the general
population. This disease is characterized by persistent articular inflammation and joint …

NLRP3 inflammasome: checkpoint connecting innate and adaptive immunity in autoimmune diseases

Y Zhang, W Yang, W Li, Y Zhao - Frontiers in immunology, 2021 - frontiersin.org
Autoimmune diseases are a broad spectrum of human diseases that are characterized by
the breakdown of immune tolerance and the production of autoantibodies. Recently …

The role of inflammasomes in human diseases and their potential as therapeutic targets

J Yao, K Sterling, Z Wang, Y Zhang… - Signal Transduction and …, 2024 - nature.com
Inflammasomes are large protein complexes that play a major role in sensing inflammatory
signals and triggering the innate immune response. Each inflammasome complex has three …

NLRP3 inflammasome activation contributes to the pathogenesis of rheumatoid arthritis

C Guo, R Fu, S Wang, Y Huang, X Li… - Clinical & …, 2018 - academic.oup.com
Nucleotide-binding, oligomerization domain (NOD)-like receptor family, pyrin domain
containing 3 (NLRP3) gene polymorphism was reported to be associated with susceptibility …