Stroke is a major cause of death and adult disability. However, therapeutic options remain
limited. Numerous pathways underlie acute responses of brain tissue to stroke. Early events …

Despite substantial investments by government, philanthropic, and commercial sources over
the past several decades, traumatic brain injury (TBI) remains an unmet medical need and a …

Traumatic brain injury (TBI) is a complex and heterogeneous disorder with a tremendous
public health burden. It is grossly defined as an alteration in brain function or other evidence …

The sulfonylurea receptor 1 (Sur1)-regulated NCCa-ATP channel is a nonselective cation
channel that is regulated by intracellular calcium and adenosine triphosphate. The channel …

The glutamate receptor was one of the most intensely investigated targets for
neuroprotection. However, numerous clinical trials of glutamate receptor antagonists for the …

The global burden of stroke remains high, and of the various subtypes of stroke, large vessel
occlusions (LVOs) account for the largest proportion of stroke-related death and disability …

Acute spinal cord injury (SCI) causes progressive hemorrhagic necrosis (PHN), a poorly
understood pathological process characterized by hemorrhage and necrosis that leads to …

Abstract Background and Aims Stress hyperglycemia is frequent in patients with acute
ischemic stroke. However, it is unclear whether stress hyperglycemia only reflects stroke …

Background Neuroprotection for ischemic stroke is a growing field, built upon the elucidation
of the biochemical pathways of ischemia first studied in the 1970s. Beginning in the early …

Background and Purpose—Ischemia/hypoxia induces de novo expression of the
sulfonylurea receptor 1-regulated NC (Ca-ATP) channel. In rodent models of ischemic …