Long non-coding RNA: Classification, biogenesis and functions in blood cells
While there exist some long non-coding RNAs (lncRNAs) that are structurally similar to
mRNAs (capped, spliced, poly a tail), not all of the lncRNAs exhibit these features …
mRNAs (capped, spliced, poly a tail), not all of the lncRNAs exhibit these features …
Role of microRNAs, circRNAs and long noncoding RNAs in acute myeloid leukemia
Acute myeloid leukemia (AML) is a malignant tumor of the immature myeloid hematopoietic
cells in the bone marrow (BM). It is a highly heterogeneous disease, with rising morbidity …
cells in the bone marrow (BM). It is a highly heterogeneous disease, with rising morbidity …
A nuclear long non-coding RNA LINC00618 accelerates ferroptosis in a manner dependent upon apoptosis
Z Wang, X Chen, N Liu, Y Shi, Y Liu, L Ouyang, S Tam… - Molecular Therapy, 2021 - cell.com
Ferroptosis is primarily caused by intracellular iron catalytic activity and lipid peroxidation.
The potential interplay between ferroptosis and apoptosis remains poorly understood. Here …
The potential interplay between ferroptosis and apoptosis remains poorly understood. Here …
An integrated genome-wide CRISPRa approach to functionalize lncRNAs in drug resistance
Resistance to chemotherapy plays a significant role in cancer mortality. To identify genetic
units affecting sensitivity to cytarabine, the mainstay of treatment for acute myeloid leukemia …
units affecting sensitivity to cytarabine, the mainstay of treatment for acute myeloid leukemia …
circMYBL2, a circRNA from MYBL2, regulates FLT3 translation by recruiting PTBP1 to promote FLT3-ITD AML progression
YM Sun, WT Wang, ZC Zeng, TQ Chen… - Blood, The Journal …, 2019 - ashpublications.org
Internal tandem duplication (ITD) mutations within FMS-like tyrosine kinase-3 (FLT3) occur
in up to 30% of acute myeloid leukemia (AML) patients and confer a very poor prognosis …
in up to 30% of acute myeloid leukemia (AML) patients and confer a very poor prognosis …
[HTML][HTML] Long non-coding RNA NEAT1 promotes non-small cell lung cancer progression through regulation of miR-377-3p-E2F3 pathway
Recently, the long non-coding RNA (lncRNA) NEAT1 has been identified as an oncogenic
gene in multiple cancer types and elevated expression of NEAT1 was tightly linked to …
gene in multiple cancer types and elevated expression of NEAT1 was tightly linked to …
Long non-coding RNA CCAL regulates colorectal cancer progression by activating Wnt/β-catenin signalling pathway via suppression of activator protein 2α
Y Ma, Y Yang, F Wang, MP Moyer, Q Wei, P Zhang… - Gut, 2016 - gut.bmj.com
Objective Long non-coding RNAs (lncRNAs) are emerging as key molecules in cancers, yet
their potential molecular mechanisms are not well understood. The objective of this study is …
their potential molecular mechanisms are not well understood. The objective of this study is …
Long noncoding RNA XIST acts as an oncogene in non-small cell lung cancer by epigenetically repressing KLF2 expression
J Fang, CC Sun, C Gong - Biochemical and biophysical research …, 2016 - Elsevier
Recently, long noncoding RNAs (lncRNAs) have been identified as critical regulators in
numerous types of cancers, including non-small cell lung cancer (NSCLC). X inactivate …
numerous types of cancers, including non-small cell lung cancer (NSCLC). X inactivate …
[HTML][HTML] Prognostic value of RDW in cancers: a systematic review and meta-analysis
L Hu, M Li, Y Ding, L Pu, J Liu, J Xie, M Cabanero, J Li… - Oncotarget, 2017 - ncbi.nlm.nih.gov
Red blood cell distribution width (RDW), a parameter that used to differentiate the type of
anemia for several decades, recent studies suggest it was a prognostic factor in various …
anemia for several decades, recent studies suggest it was a prognostic factor in various …
The lncRNA HOTAIRM1 regulates the degradation of PML-RARA oncoprotein and myeloid cell differentiation by enhancing the autophagy pathway
ZH Chen, WT Wang, W Huang, K Fang… - Cell Death & …, 2017 - nature.com
Increasing evidence has indicated that long noncoding RNAs (lncRNAs) are of great
importance in different cell contexts. However, only a very small number of lncRNAs have …
importance in different cell contexts. However, only a very small number of lncRNAs have …