Hepatitis B virus (HBV) is a para-retrovirus or retroid virus that contains a double-stranded
DNA genome and replicates this DNA via reverse transcription of a RNA pregenome. Viral …

Hemopoiesis counterbalances the continuous loss of aged blood cells. Young progeny are
generated by myeloid and lymphoid progenitors that originate from a small pool of …

Accumulation of activated immune cells results in nonspecific hepatocyte killing in chronic
hepatitis B (CHB), leading to fibrosis and cirrhosis. This study aims to understand the …

Hepatoma cell lines are frequently used as in vitro alternatives to primary human
hepatocytes. Cell lines are characterized by their unlimited life span, stable phenotype, high …

The discovery of microRNAs (miRNAs) as a new class of regulators of gene expression has
triggered an explosion of research activities, but has left many unanswered questions about …

In recent years, dozens of halogenated disinfection byproducts (DBPs) with cyclic structures
were identified and detected in drinking water globally. Previous in vivo toxicity studies have …

Considering that the development of hepatic lesions related to iron overload diseases might
be a result of abnormally expressed hepatic genes, we searched for new genes up …

The mission of the Encyclopedia of DNA Elements (ENCODE) Project is to enable the
scientific and medical communities to interpret the human genome sequence and apply it to …

Among numerous established human hepatoma cell lines, none has been shown
susceptible to hepatitis B virus (HBV) infection. We describe here a cell line, called HepaRG …

Hepatocellular carcinoma (HCC) remains a global challenge due to high morbidity and
mortality rates and poor response to treatment. Immunotherapy, based on introduction of …