Protein homeostasis or proteostasis is an essential balance of cellular protein levels
mediated through an extensive network of biochemical pathways that regulate different …

This systematic review critically evaluates the literature to identify the demographic and
clinical factors that predict the health-related quality of life (HRQOL) of people with …

Aim: To compare quality of life, level of disability, and caregiver burden in 3 groups of people
with Parkinson disease (PD): those with mild cognitive impairment (PD-MCI), those with …

Background Depression is common in patients with Parkinson's disease, but evidence on
the efficacy of antidepressants in this population is lacking. Because depression in patients …

Background: Parkinson disease (PD) is a common neurodegenerative disease affecting up
to 1 million individuals in the United States. Depression affects up to 50% of these patients …

Background Health-related quality of life (HRQoL) is emerging as an important element of
clinical research in primary headache disorders, allowing a measure of the impact of …

Objective: To identify factors that independently contribute to disability and quality of life
(QoL) in patients with mild to moderate Parkinson disease (PD). Methods: A group of 190 …

Non-motor symptoms in patients with Parkinson's disease (PD) are often poorly recognized,
significantly impair quality of life and cause severe disability. Currently, there is limited …

Parkinson's disease is a complex neurodegenerative disorder characterized by motor and
non-motor symptoms, with neuropsychiatric manifestations among the most frequent non …

Only a few years after the introduction of levodopa, the first descriptions of motor fluctuations
and dyskinesia related to dopaminergic therapy appeared. In PD, attention turned to their …