Age-associated epigenetic changes in mammalian sperm: implications for offspring health and development

V Ashapkin, A Suvorov, JR Pilsner… - Human reproduction …, 2023 - academic.oup.com
BACKGROUND Modern reproductive behavior in most developed countries is characterized
by delayed parenthood. Older gametes are generally less fertile, accumulating and …

[HTML][HTML] Lifestyle causes of male infertility

D Durairajanayagam - Arab journal of urology, 2018 - Elsevier
Objective To examine the potential effects of lifestyle factors on male reproductive health.
Evidence of a global decline in human sperm quality over recent decades has been …

Advanced paternal age is associated with an increased risk of spontaneous miscarriage: a systematic review and meta-analysis

NA Du Fossé, MLP Van der Hoorn… - Human reproduction …, 2020 - academic.oup.com
BACKGROUND Although spontaneous miscarriage is the most common complication of
human pregnancy, potential contributing factors are not fully understood. Advanced …

Impact of advanced paternal age on fertility and risks of genetic disorders in offspring

A Kaltsas, E Moustakli, A Zikopoulos, I Georgiou… - Genes, 2023 - mdpi.com
The average age of fathers at first pregnancy has risen significantly over the last decade
owing to various variables, including a longer life expectancy, more access to contraception …

Effects of increased paternal age on sperm quality, reproductive outcome and associated epigenetic risks to offspring

R Sharma, A Agarwal, VK Rohra, M Assidi… - Reproductive Biology …, 2015 - Springer
Over the last decade, there has been a significant increase in average paternal age when
the first child is conceived, either due to increased life expectancy, widespread use of …

Male reproductive ageing: a radical road to ruin

RJ Aitken - Human Reproduction, 2023 - academic.oup.com
In modern post-transition societies, we are reproducing later and living longer. While the
impact of age on female reproductive function has been well studied, much less is known …

A treatment approach for couples with disrupted sperm DNA integrity and recurrent ART failure

A Parrella, D Keating, S Cheung, P Xie… - Journal of assisted …, 2019 - Springer
Objective To test a novel method to select spermatozoa with high chromatin integrity. Design
Specimens with high sperm chromatin fragmentation (SCF) were selected by density …

[HTML][HTML] Impact of age, clinical conditions, and lifestyle on routine semen parameters and sperm kinematics

GL Verón, AD Tissera, R Bello, F Beltramone… - Fertility and sterility, 2018 - Elsevier
Objective To assess the impact of aging on routine semen and computer-assisted sperm
analysis (CASA) motility parameters according to the current World Health Organization …

[HTML][HTML] Age-related changes in human sperm DNA integrity

A Rosiak-Gill, K Gill, J Jakubik, M Fraczek… - Aging (Albany …, 2019 - ncbi.nlm.nih.gov
Abnormal standard semen characteristics and reduced sperm chromatin maturity can
appear with increasing male age. However, the influence of paternal age on semen …

Paternal age: negative impact on sperm genome decays and IVF outcomes after 40 years

I Kaarouch, N Bouamoud, A Madkour… - Molecular …, 2018 - Wiley Online Library
This study assessed sperm quality declining on relation to paternal age and its impact on in
vitro fertilization (IVF) outcomes in order to estimate the APA (Advanced Paternal Age) cutoff …