Synaptic neurexin complexes: a molecular code for the logic of neural circuits

TC Südhof - Cell, 2017 - cell.com
Synapses are specialized junctions between neurons in brain that transmit and compute
information, thereby connecting neurons into millions of overlapping and interdigitated …

Inhibition in the amygdala anxiety circuitry

O Babaev, C Piletti Chatain… - Experimental & molecular …, 2018 - nature.com
Inhibitory neurotransmission plays a key role in anxiety disorders, as evidenced by the
anxiolytic effect of the benzodiazepine class of γ-aminobutyric acid (GABA) receptor …

Glutamatergic dysfunction and synaptic ultrastructural alterations in schizophrenia and autism spectrum disorder: Evidence from human and rodent studies

A Eltokhi, A Santuy, A Merchan-Perez… - International journal of …, 2020 - mdpi.com
The correlation between dysfunction in the glutamatergic system and neuropsychiatric
disorders, including schizophrenia and autism spectrum disorder, is undisputed. Both …

Genome-wide association study reveals candidate genes for litter size traits in pelibuey sheep

W Hernández-Montiel, MA Martínez-Núñez… - Animals, 2020 - mdpi.com
Simple Summary Reproductive traits are economically important in the livestock industry,
and this is of greater relevance when it comes to indigenous animals, since their study …

Activation of the CaMKII-Sarm1-ASK1-p38 MAP kinase pathway protects against axon degeneration caused by loss of mitochondria

C Ding, Y Wu, H Dabas, M Hammarlund - Elife, 2022 - elifesciences.org
Mitochondrial defects are tightly linked to axon degeneration, yet the underlying cellular
mechanisms remain poorly understood. In Caenorhabditis elegans, PVQ axons that lack …

Evaluating the effects of grain of isogenic wheat lines differing in the content of anthocyanins in mouse models of neurodegenerative disorders

MA Tikhonova, OY Shoeva, MV Tenditnik… - Nutrients, 2020 - mdpi.com
Functional foods enriched with plant polyphenols and anthocyanins in particular attract
special attention due to multiple beneficial bioactive properties of the latter. We evaluated …

CHRNA5 links chandelier cells to severity of amyloid pathology in aging and Alzheimer's disease

J Rybnicek, Y Chen, M Milic, ES Tio… - Translational …, 2024 - nature.com
Abstract Changes in high-affinity nicotinic acetylcholine receptors are intricately connected
to neuropathology in Alzheimer's Disease (AD). Protective and cognitive-enhancing roles for …

Organizers of inhibitory synapses come of age

D Krueger-Burg, T Papadopoulos, N Brose - Current Opinion in …, 2017 - Elsevier
Highlights•The protein machinery at inhibitory synapses is more complex than
anticipated.•Many new synapse organizers have recently been identified.•Major progress …

Early environmental exposure to oxytetracycline in Danio rerio may contribute to neurobehavioral abnormalities in adult zebrafish

K Yu, Y Qiu, Y Shi, X Yu, B Zhou, T Sun, Y Wu… - Science of The Total …, 2023 - Elsevier
The common antibiotic oxytetracycline (OTC) is nowadays commonly found in natural
aquatic environments. However, the underlying mechanisms of low-dose OTC exposure and …

Adaptation of magnified analysis of the proteome for excitatory synaptic proteins in varied samples and evaluation of cell type-specific distributions

M Delhaye, J LeDue, K Robinson, Q Xu… - Journal of …, 2024 - Soc Neuroscience
Growing evidence suggests a remarkable diversity and complexity in the molecular
composition of synapses, forming the basis for the brain to execute complex behaviors …