Cells have a remarkable ability to synthesize large amounts of protein in a very short period
of time. Under these conditions, many hydrophobic surfaces on proteins may be transiently …

Living organisms are surrounded with heavy metals such as methylmercury, manganese,
cobalt, cadmium, arsenic, as well as pesticides such as deltamethrin and paraquat, or …

Living organisms are endowed with the capability to tackle various forms of cellular stress
due to the presence of molecular chaperone machinery complexes that are ubiquitous …

Highlights•Basic mechanism for all the discussed click reaction has been shown.•Many new
enzyme inhibitors was identified by drug discovery using click approaches.•Drug delivery by …

Heat shock factor 1 (HSF1) monitors the structural integrity of the proteome. Phosphorylation
at S326 is a hallmark for HSF1 activation, but the identity of the kinase (s) phosphorylating …

Prostate cancer (PCa) is one of the most common cancer types in men worldwide. Heat
shock proteins (HSPs) are molecular chaperones that are widely implicated in the …

Cruciferous vegetables are rich sources of glucosinolates which are the biogenic precursor
molecules of isothiocyanates (ITCs). The relationship between the consumption of …

Sustained androgen receptor (AR) signaling and apoptosis evasion are among the main
hurdles of castration‐resistant prostate cancer (CRPC) treatment. We designed and …

Background The isothiocyanate sulforaphane (SFN) has multiple protein targets in
mammalian cells, affecting processes of fundamental importance for the maintenance of …

Autism spectrum disorder (ASD) is a complex, life-long neurodevelopmental disorder
currently affecting an estimated 1 out of 68 among children aged 8 y in the United States …