Mycobacterium tuberculosis uses sophisticated secretion systems, named 6 kDa early
secretory antigenic target (ESAT6) protein family secretion (ESX) systems (also known as …

Tuberculosis continues to kill 1· 4 million people annually. During the past 5 years, an
alarming increase in the number of patients with multidrug-resistant tuberculosis and …

Mycobacterium tuberculosis (Mtb) encodes five type VII secretion systems (T7SS),
designated ESX-1–ESX-5, that are critical for growth and pathogenesis. The best …

The secreted Mycobacterium tuberculosis complex proteins CFP‐10 and ESAT‐6 have
recently been shown to play an essential role in tuberculosis pathogenesis. We have …

BCG turns 100 this year and while it might not be the perfect vaccine, it has certainly
contributed significantly towards eradication and prevention of spread of tuberculosis (TB) …

The 6kDa early secreted antigenic target from Mycobacterium tuberculosis, ESAT-6, is the
prototype of a novel family of small proteins of unknown function produced by …

Mycobacterium tuberculosis (Mtb) disrupts anti-microbial pathways of macrophages, cells
that normally kill bacteria. Over 40 years ago, D'Arcy Hart showed that Mtb avoids delivery to …

Previously we have shown that Ag85B-ESAT-6 is a highly efficient vaccine against
tuberculosis. However, because the ESAT-6 Ag is also an extremely valuable diagnostic …

Tuberculosis (TB), an ancient human scourge, is a growing health problem in the
developing world. Approximately two million deaths each year are caused by TB, which is …

Efforts over the last 2 decades have led to a rich research and development pipeline of
tuberculosis (TB) vaccines. Although none of the candidates has successfully completed the …