Osteogenesis imperfecta in children and adolescents—new developments in diagnosis and treatment
P Trejo, F Rauch - Osteoporosis International, 2016 - Springer
Osteogenesis imperfecta (OI) is the most prevalent heritable bone fragility disorder in
children. It has been known for three decades that the majority of individuals with OI have …
children. It has been known for three decades that the majority of individuals with OI have …
Osteogenesis imperfecta–a clinical update
S Tournis, AD Dede - Metabolism, 2018 - Elsevier
Osteogenesis imperfecta (OI) is the most common inherited form of bone fragility and
includes a heterogenous group of genetic disorders which most commonly result from …
includes a heterogenous group of genetic disorders which most commonly result from …
BPS804 anti‐sclerostin antibody in adults with moderate osteogenesis imperfecta: results of a randomized phase 2a trial
FH Glorieux, JP Devogelaer, M Durigova… - Journal of Bone and …, 2017 - academic.oup.com
ABSTRACT This 21‐week, open‐label, phase 2a trial aimed to evaluate the
pharmacodynamics and safety of multiple, escalating infusions of BPS804, a neutralizing …
pharmacodynamics and safety of multiple, escalating infusions of BPS804, a neutralizing …
Approach to the patient: pharmacological therapies for fracture risk reduction in adults with osteogenesis imperfecta
W Liu, B Lee, SCS Nagamani, L Nicol… - The Journal of …, 2023 - academic.oup.com
Context Osteogenesis imperfecta (OI) is a genetic disorder characterized by increased bone
fragility largely caused by defects in structure, synthesis, or post-translational processing of …
fragility largely caused by defects in structure, synthesis, or post-translational processing of …
Genetic risk factors for atypical femoral fractures (AFFs): a systematic review
HH Nguyen, DM van de Laarschot… - Journal of Bone and …, 2018 - academic.oup.com
Atypical femoral fractures (AFFs) are uncommon and have been associated particularly with
long term antiresorptive therapy, including bisphosphonates. Although the pathogenesis of …
long term antiresorptive therapy, including bisphosphonates. Although the pathogenesis of …
Diaphyseal femur fractures in osteogenesis imperfecta: characteristics and relationship with bisphosphonate treatment
P Trejo, F Fassier, FH Glorieux… - Journal of Bone and …, 2017 - academic.oup.com
Several recent case reports have suggested that bisphosphonate treatment in individuals
with osteogenesis imperfecta (OI) is causally related to atypical femur fractures. However, it …
with osteogenesis imperfecta (OI) is causally related to atypical femur fractures. However, it …
Orthopaedic considerations for the adult with osteogenesis imperfecta
TT Roberts, DJ Cepela, RL Uhl… - JAAOS-Journal of the …, 2016 - journals.lww.com
Osteogenesis imperfecta is a heritable group of collagen-related disorders that affects up to
50,000 people in the United States. Although the disease is most symptomatic in childhood …
50,000 people in the United States. Although the disease is most symptomatic in childhood …
High revision rate but good healing capacity of atypical femoral fractures. A comparison with common shaft fractures
J Schilcher - Injury, 2015 - Elsevier
Introduction Healing of complete, atypical femoral fractures is thought to be impaired, but the
evidence is weak and appears to be based on the delayed healing observed in patients with …
evidence is weak and appears to be based on the delayed healing observed in patients with …
Bisphosphonate treatment and the characteristics of femoral fractures in children with osteogenesis imperfecta
I Vuorimies, MK Mäyränpää, H Valta… - The Journal of …, 2017 - academic.oup.com
Context: The short-term benefits of bisphosphonates (BPs) are evident in the treatment of
children with osteogenesis imperfecta (OI), but some concerns related to long-term effects …
children with osteogenesis imperfecta (OI), but some concerns related to long-term effects …
Incidence and treatment of femur fractures in adults with osteogenesis imperfecta: an analysis of an expert clinic of 216 patients
WA Goudriaan, GJ Harsevoort, M Van Leeuwen… - European Journal of …, 2020 - Springer
Purpose Osteogenesis imperfecta (OI) is characterized by increased bone fragility and
susceptibility for fractures. A few studies described and compared treatment modalities for …
susceptibility for fractures. A few studies described and compared treatment modalities for …