Replication protein A (RPA) and RAD51 are DNA-binding proteins that help maintain
genome stability during DNA replication. These proteins regulate nucleases, helicases, DNA …

Homologous recombination (HR) is a major pathway for the repair of DNA double-strand
breaks in mammalian cells, the defining step of which is homologous strand exchange …

BRCA2-mutant cells are defective in homologous recombination, making them vulnerable to
the inactivation of other pathways for the repair of DNA double-strand breaks (DSBs). This …

DNA double-strand breaks arise accidentally upon exposure of DNA to radiation and
chemicals or result from faulty DNA metabolic processes. DNA breaks can also be …

Recombinational DNA repair is a universal aspect of DNA metabolism and is essential for
genomic integrity. It is a template-directed process that uses a second chromosomal copy …

The proteins encoded by the two major breast cancer susceptibility genes, BRCA1 and
BRCA2, work in a common pathway of genome protection. However, the two proteins work …

Accurate DNA repair and replication are critical for genomic stability and cancer prevention.
RAD51 and its gene family are key regulators of DNA fidelity through diverse roles in double …

Mitotic homologous recombination promotes genome stability through the precise repair of
DNA double-strand breaks and other lesions that are encountered during normal cellular …

Homologous recombination (HR) is critical both for repairing DNA lesions in mitosis and for
chromosomal pairing and exchange during meiosis. However, some forms of HR can also …

Faithful DNA replication is essential to all life. Hydroxyurea (HU) depletes the cells of dNTPs,
which initially results in stalled replication forks that, after prolonged treatment, collapse into …