Abstract Background Topologically associating domains (TADs) are locally highly-
interacting genome regions, which also play a critical role in regulating gene expression in …

Chromatin conformation plays an important role in a variety of genomic processes. Hi-C is
one of the most popular assays for inspecting chromatin conformation. However, the utility of …

Topologically associating domains (TADs) are local chromatin interaction domains, which
have been shown to play an important role in gene expression regulation. TADs were …

Chromatin conformation plays an important role in a variety of genomic processes. Hi-C is
one of the most popular assays for inspecting chromatin conformation. However, the utility of …

Hi-C matrices describe the genome-wide contact probability between chromatin loci. The
comparison of Hi-C matrices is important both to assess the reproducibility in biological …

The rapidly increasing three-dimensional genome-wide data produced by chromosome
conformation capture presents many challenges in computational biology to understand the …

This dissertation, submitted as a partial requirement for completion of the Doctorate of
Philosophy, outlines the research performed by Max Highsmith in the BDM Lab. This work …