[HTML][HTML] Genetic and brain similarity independently predict childhood anthropometrics and neighborhood socioeconomic conditions
A Dahl, EM Eilertsen, SF Rodriguez-Cabello… - Developmental …, 2024 - Elsevier
Linking the developing brain with individual differences in clinical and demographic traits is
challenging due to the substantial interindividual heterogeneity of brain anatomy and …
challenging due to the substantial interindividual heterogeneity of brain anatomy and …
[HTML][HTML] Genomic findings and their implications for the evolutionary social sciences
BP Zietsch - Evolution and Human Behavior, 2024 - Elsevier
What past selection pressures have shaped human traits and their variation and covariation
across individuals? These are key questions in the evolutionary social sciences. Recent …
across individuals? These are key questions in the evolutionary social sciences. Recent …
Leveraging fine-scale population structure reveals conservation in genetic effect sizes between human populations across a range of human phenotypes
An understanding of genetic differences between populations is essential for avoiding
confounding in genome-wide association studies (GWAS) and understanding the evolution …
confounding in genome-wide association studies (GWAS) and understanding the evolution …
An effective hyper-parameter can increase the prediction accuracy in a single-step genetic evaluation
The H-matrix best linear unbiased prediction (HBLUP) method has been widely used in
livestock breeding programs. It can integrate all information, including pedigree, genotypes …
livestock breeding programs. It can integrate all information, including pedigree, genotypes …
MultiSuSiE improves multi-ancestry fine-mapping in All of Us whole-genome sequencing data
Leveraging data from multiple ancestries can greatly improve fine-mapping power due to
differences in linkage disequilibrium and allele frequencies. We propose MultiSuSiE, an …
differences in linkage disequilibrium and allele frequencies. We propose MultiSuSiE, an …
Cross-ancestry genetic architecture and prediction for cholesterol traits
While cholesterol is essential, a high level of cholesterol is associated with the risk of
cardiovascular diseases. Genome-wide association studies (GWASs) have proven …
cardiovascular diseases. Genome-wide association studies (GWASs) have proven …
R2ROC: An efficient method of comparing two or more correlated AUC from out-of-sample prediction using polygenic scores
Polygenic risk scores (PRSs) enable early prediction of disease risk. Evaluating PRS
performance for binary traits commonly relies on the area under the receiver operating …
performance for binary traits commonly relies on the area under the receiver operating …
Implications of self-identified race, ethnicity, and genetic ancestry on genetic association studies in biobanks within health systems
R Johnson, B Pasaniuc - arXiv preprint arXiv:2402.15696, 2024 - arxiv.org
Precision medicine aims to create biomedical solutions tailored to specific factors that affect
disease risk and treatment responses within the population. The success of the genomics …
disease risk and treatment responses within the population. The success of the genomics …
[HTML][HTML] Controlling for polygenic genetic confounding in epidemiologic association studies
Epidemiologic associations estimated from observational data are often confounded by
genetics due to pervasive pleiotropy among complex traits. Many studies either neglect …
genetics due to pervasive pleiotropy among complex traits. Many studies either neglect …
Genetic and brain similarity independently predict childhood anthropometrics and socioeconomic markers
Linking the developing brain with individual differences in clinical and demographic traits is
challenging due to the substantial interindividual heterogeneity of brain anatomy and …
challenging due to the substantial interindividual heterogeneity of brain anatomy and …