Hypoxia inducible factor as a therapeutic target for atherosclerosis

T Jain, EA Nikolopoulou, Q Xu, A Qu - Pharmacology & therapeutics, 2018 - Elsevier
Atherosclerosis is a highly prevalent disease that can significantly increase the risk of major
vascular events, such as myocardial or cerebral infarctions. The anoxemia theory states that …

[HTML][HTML] The role and therapeutic potential of nuclear factor κB (NF-κB) in ischemic stroke

G Xu, F Dong, L Su, ZX Tan, M Lei, L Li, D Wen… - Biomedicine & …, 2024 - Elsevier
Stroke is a prevalent cerebrovascular condition with a global impact, causing significant
rates of illness and death. Despite extensive research, the available treatment options for …

Vascular changes and hypoxia in periodontal disease as a link to systemic complications

D Celik, A Kantarci - Pathogens, 2021 - mdpi.com
The hypoxic microenvironment caused by oral pathogens is the most important cause of the
disruption of dynamic hemostasis between the oral microbiome and the immune system …

Mitochondrial metabolism as target of the neuroprotective role of erythropoietin in Parkinson's disease

F Rey, S Ottolenghi, T Giallongo, A Balsari, C Martinelli… - Antioxidants, 2021 - mdpi.com
Existing therapies for Parkinson's disease (PD) are only symptomatic. As erythropoietin
(EPO) is emerging for its benefits in neurodegenerative diseases, here, we test the …

Hypoxia in atherogenesis

GAA Ferns, L Heikal - Angiology, 2017 - journals.sagepub.com
The anoxemia theory proposes that an imbalance between the demand for and supply of
oxygen in the arterial wall is a key factor in the development of atherosclerosis. There is now …

3D bioprinting of novel biocompatible scaffolds for endothelial cell repair

Y Wu, L Heikal, G Ferns, P Ghezzi, A Nokhodchi… - Polymers, 2019 - mdpi.com
The aim of this study was to develop and evaluate an optimized 3D bioprinting technology in
order to fabricate novel scaffolds for the application of endothelial cell repair. Various …

Flow Mediated Skin Fluorescence technique reveals remarkable effect of age on microcirculation and metabolic regulation in type 1 diabetes

J Katarzynska, A Borkowska, P Czajkowski, A Los… - Microvascular …, 2019 - Elsevier
Abstract Study description Flow Mediated Skin Fluorescence (FMSF) is a novel technique for
non-invasive evaluation of the microcirculation and metabolic regulation. This study …

Can erythropoietin reduce hypoxemic neurological damages in neonates with congenital heart defects?

S Ottolenghi, G Milano, MD Cas, TO Findley… - Frontiers in …, 2021 - frontiersin.org
Congenital heart defects (CHD), the most common cause of birth defects with increasing
birth prevalence, affect nearly 1% of live births worldwide. Cyanotic CHD are characterized …

Recovery from experimental parkinsonism by intrastriatal application of erythropoietin or EPO-releasing neural precursors

S Carelli, T Giallongo, C Viaggi, E Latorre… - …, 2017 - Elsevier
An extensive literature has shown a powerful neuroprotective action of Erythropoietin (EPO)
both in vivo and in vitro. This study shows that EPO, whether ectopically administered or …

[HTML][HTML] Activation of the EPOR-β common receptor complex by cibinetide ameliorates impaired wound healing in mice with genetic diabetes

A Bitto, N Irrera, G Pizzino, G Pallio, F Mannino… - … et Biophysica Acta (BBA …, 2018 - Elsevier
Diabetes is characterized by poor wound healing which currently lacks an efficacious
treatment. The innate repair receptor (IRR) is a master regulator of tissue protection and …