Genome-wide association studies of cancer: current insights and future perspectives
Genome-wide association studies (GWAS) provide an agnostic approach for investigating
the genetic basis of complex diseases. In oncology, GWAS of nearly all common …
the genetic basis of complex diseases. In oncology, GWAS of nearly all common …
Single-cell analysis of somatic mutations in human bronchial epithelial cells in relation to aging and smoking
Z Huang, S Sun, M Lee, AY Maslov, M Shi… - Nature …, 2022 - nature.com
Although lung cancer risk among smokers is dependent on smoking dose, it remains
unknown if this increased risk reflects an increased rate of somatic mutation accumulation in …
unknown if this increased risk reflects an increased rate of somatic mutation accumulation in …
Metastatic non-small-cell lung cancer: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up
S Novello, F Barlesi, R Califano, T Cufer… - Annals of …, 2016 - annalsofoncology.org
Primary lung cancer remains the most common malignancy after non-melanocytic skin
cancer, and deaths from lung cancer exceed those from any other malignancy worldwide [1] …
cancer, and deaths from lung cancer exceed those from any other malignancy worldwide [1] …
Rare variants of large effect in BRCA2 and CHEK2 affect risk of lung cancer
Y Wang, JD McKay, T Rafnar, Z Wang, MN Timofeeva… - Nature …, 2014 - nature.com
We conducted imputation to the 1000 Genomes Project of four genome-wide association
studies of lung cancer in populations of European ancestry (11,348 cases and 15,861 …
studies of lung cancer in populations of European ancestry (11,348 cases and 15,861 …
Understanding TERT promoter mutations: a common path to immortality
RJA Bell, HT Rube, A Xavier-Magalhaes… - Molecular Cancer …, 2016 - AACR
Telomerase (TERT) activation is a fundamental step in tumorigenesis. By maintaining
telomere length, telomerase relieves a main barrier on cellular lifespan, enabling limitless …
telomere length, telomerase relieves a main barrier on cellular lifespan, enabling limitless …
[HTML][HTML] SCLC: epidemiology, risk factors, genetic susceptibility, molecular pathology, screening, and early detection
We review research regarding the epidemiology, risk factors, genetic susceptibility,
molecular pathology, and early detection of SCLC, a deadly tumor that accounts for 14% of …
molecular pathology, and early detection of SCLC, a deadly tumor that accounts for 14% of …
A decade of GWAS results in lung cancer
Genome-wide association studies (GWAS) were successful to identify genetic factors
robustly associated with lung cancer. This review aims to synthesize the literature in this field …
robustly associated with lung cancer. This review aims to synthesize the literature in this field …
[HTML][HTML] DNA methylation age of blood predicts future onset of lung cancer in the women's health initiative
Lung cancer is considered an age-associated disease, whose progression is in part due to
accumulation of genomic instability as well as age-related decline in system integrity and …
accumulation of genomic instability as well as age-related decline in system integrity and …
Multiple independent variants at the TERT locus are associated with telomere length and risks of breast and ovarian cancer
TERT-locus SNPs and leukocyte telomere measures are reportedly associated with risks of
multiple cancers. Using the Illumina custom genotyping array iCOGs, we analyzed∼ 480 …
multiple cancers. Using the Illumina custom genotyping array iCOGs, we analyzed∼ 480 …
Telomeric and extra-telomeric roles for telomerase and the telomere-binding proteins
P Martínez, MA Blasco - Nature Reviews Cancer, 2011 - nature.com
Mammalian telomeres are formed by tandem repeats of the TTAGGG sequence, which are
progressively lost with each round of cell division. Telomere protection requires a minimal …
progressively lost with each round of cell division. Telomere protection requires a minimal …