Over the last years, hypothalamic inflammation has been linked to the development and
progression of obesity and its sequelae. There is accumulating evidence that this …

Metabolic dysfunction contributes to the clinical deterioration observed in advanced cancer
patients and is characterized by weight loss, skeletal muscle wasting, and atrophy of the …

Thermogenesis, the production of heat energy, is the specific, neurally regulated, metabolic
function of brown adipose tissue (BAT) and contributes to the maintenance of body …

Background In experimental models, hypothalamic inflammation is an early and determining
factor in the installation and progression of obesity. Pharmacological and gene-based …

Under conditions leading to aging and metabolic syndrome, the hypothalamus atypically
undergoes proinflammatory signaling activation leading to a chronic and stable background …

Cachexia is a wasting disorder that accompanies many chronic diseases including cancer
and results from an imbalance of energy requirements and energy uptake. In cancer …

Diet-induced obesity leads to devastating and common chronic diseases, fueling ongoing
interest in determining new mechanisms underlying both obesity and its consequences. It is …

Cachexia has a devastating impact on survival and quality of life for many cancer patients. A
better understanding of the underlying mechanisms leading to the complex metabolic …

When challenged with a variety of inflammatory threats, multiple systems across the body
undergo physiological responses to promote defense and survival. The constellation of …

Hypothalamic inflammation is present in animal models of obesity, and the
intracerebroventricular injection of TNFα can reproduce a number of features of the …