Improving the human hazard characterization of chemicals: a Tox21 update
RR Tice, CP Austin, RJ Kavlock… - Environmental health …, 2013 - ehp.niehs.nih.gov
Background: In 2008, the National Institute of Environmental Health Sciences/National
Toxicology Program, the US Environmental Protection Agency's National Center for …
Toxicology Program, the US Environmental Protection Agency's National Center for …
Comparison of toxicogenomics and traditional approaches to inform mode of action and points of departure in human health risk assessment of benzo[a]pyrene in …
I Moffat, NL Chepelev, S Labib… - Critical reviews in …, 2015 - Taylor & Francis
Toxicogenomics is proposed to be a useful tool in human health risk assessment. However,
a systematic comparison of traditional risk assessment approaches with those applying …
a systematic comparison of traditional risk assessment approaches with those applying …
The comparative toxicogenomics database: update 2019
AP Davis, CJ Grondin, RJ Johnson… - Nucleic acids …, 2019 - academic.oup.com
Abstract The Comparative Toxicogenomics Database (CTD; http://ctdbase. org/) is a premier
public resource for literature-based, manually curated associations between chemicals …
public resource for literature-based, manually curated associations between chemicals …
The comparative toxicogenomics database: update 2011
Abstract The Comparative Toxicogenomics Database (CTD) is a public resource that
promotes understanding about the interaction of environmental chemicals with gene …
promotes understanding about the interaction of environmental chemicals with gene …
MEDIC: a practical disease vocabulary used at the Comparative Toxicogenomics Database
Abstract The Comparative Toxicogenomics Database (CTD) is a public resource that
promotes understanding about the effects of environmental chemicals on human health …
promotes understanding about the effects of environmental chemicals on human health …
A population approach to precision medicine
The term P4 medicine is used to denote an evolving field of medicine that uses systems
biology approaches and information technologies to enhance wellness rather than just treat …
biology approaches and information technologies to enhance wellness rather than just treat …
[HTML][HTML] Shared causal paths underlying Alzheimer's dementia and type 2 diabetes
Z Hu, R Jiao, P Wang, Y Zhu, J Zhao, P De Jager… - Scientific reports, 2020 - nature.com
Although Alzheimer's disease (AD) is a central nervous system disease and type 2 diabetes
MELLITUS (T2DM) is a metabolic disorder, an increasing number of genetic epidemiological …
MELLITUS (T2DM) is a metabolic disorder, an increasing number of genetic epidemiological …
A combined analysis of genome-wide association studies in breast cancer
J Li, K Humphreys, T Heikkinen, K Aittomäki… - Breast cancer research …, 2011 - Springer
In an attempt to identify common disease susceptibility alleles for breast cancer, we
performed a combined analysis of three genome-wide association studies (GWAS) …
performed a combined analysis of three genome-wide association studies (GWAS) …
Lessons from toxicology: developing a 21st-century paradigm for medical research
G Langley, CP Austin, AK Balapure… - Environmental …, 2015 - ehp.niehs.nih.gov
Biomedical developments in the 21st century provide an unprecedented opportunity to gain
a dynamic systems-level and human-specific understanding of the causes and …
a dynamic systems-level and human-specific understanding of the causes and …
[HTML][HTML] Perspectives on validation of high-throughput assays supporting 21st century toxicity testing
In vitro, high-throughput screening (HTS) assays are seeing increasing use in toxicity
testing. HTS assays can simultaneously test many chemicals, but have seen limited use in …
testing. HTS assays can simultaneously test many chemicals, but have seen limited use in …