Through their many and varied metabolic functions, mitochondria power life. Paradoxically,
mitochondria also have a central role in apoptotic cell death. Upon induction of …

Inflammasomes are inflammatory signaling complexes that provide molecular platforms to
activate the protease function of inflammatory caspases. Caspases-1,-4,-5, and-11 are …

Members of the caspase family of proteases play essential roles in the initiation and
execution of apoptosis. These caspases are divided into two groups: the initiator caspases …

In multicellular organisms, cell death is a critical and active process that maintains tissue
homeostasis and eliminates potentially harmful cells. There are three major types of …

Host-protective caspase-1 activity must be tightly regulated to prevent pathology, but
mechanisms controlling the duration of cellular caspase-1 activity are unknown. Caspase-1 …

Caspases are the primary drivers of apoptotic cell death, cleaving cellular proteins that are
critical for dismantling the dying cell. Initially translated as inactive zymogenic precursors …

Apoptosis, a form of programmed cell death, is responsible for eliminating damaged or
unnecessary cells in multicellular organisms. Various types of intracellular stress trigger …

Mitochondrial outer membrane permeabilization (MOMP) is often required for activation of
the caspase proteases that cause apoptotic cell death. Various intermembrane space (IMS) …

Although required for life, paradoxically, mitochondria are often essential for initiating
apoptotic cell death. Mitochondria regulate caspase activation and cell death through an …

As the most intensively studied initiator caspase, caspase-9 is a key player in the intrinsic or
mitochondrial pathway which is involved in various stimuli, including chemotherapies, stress …