Japanese encephalitis virus (JEV), a mosquito-borne zoonotic flavivirus, is an enveloped
positive-strand RNA virus that can cause a spectrum of clinical manifestations, ranging from …

Sexual reproduction is almost universal in eukaryotic life and involves the fusion of male and
female haploid gametes into a diploid cell. The sperm-restricted single-pass transmembrane …

Highlights•Until 2013, class II proteins had only been found in flaviviruses and
alphaviruses.•A class II fusion protein was recently discovered in the unrelated phlebovirus …

Hantaviruses are rodent-borne viruses causing serious zoonotic outbreaks worldwide for
which no treatment is available. Hantavirus particles are pleomorphic and display a …

Although several different flaviviruses may cause encephalitis, Japanese encephalitis virus
is the most significant, being responsible for thousands of deaths each year in Asia. The …

Cell-cell fusion proteins are essential in development. Here we show that the C. elegans cell-
cell fusion protein EFF-1 is structurally homologous to viral class II fusion proteins. The 2.6 Å …

The final stages of dengue virus fusion are thought to occur when the membrane-proximal
stem drives the transmembrane anchor of the viral envelope protein (E) toward the fusion …

Yellow fever virus (YFV), a deadly human pathogen, is the prototype of the genus Flavivirus.
Recently, YFV re-emerged in Africa and Brazil, leading to hundreds of deaths, with some …

Hantaviruses are important emerging human pathogens and are the causative agents of
serious diseases in humans with high mortality rates. Like other members in the …

A number of structures have been solved for the Envelope (E) protein from dengue virus and
closely related flaviviruses, providing detailed pictures of the conformational states of the …