Healthy pregnancies are fundamental to healthy populations, but very few therapies to
improve pregnancy outcomes are available. Fundamental concepts—for example …

Nearly 70% of preterm deliveries occur spontaneously, and the clinical pathways involved
include preterm labor and preterm premature rupture of membranes. Prediction of preterm …

Background In order to identify and possibly offer prophylactic treatment to women at risk for
preterm birth (PTB), novel prediction models for PTB are needed. Our objective was to utilize …

Preterm birth (PTB) is a leading cause of neonatal morbidity and mortality worldwide, yet the
cellular and molecular mechanisms driving this condition remain undeciphered, thus limiting …

Abstract Background Interleukin (IL)-6 is a pro-inflammatory cytokine that plays an important
role in preterm birth (PTB), Several meta-analyses investigated the association between IL-6 …

Chorion trophoblasts (CTCs) and immune cell-enriched decidua (DECs) comprise the
maternal-fetal membrane interface called the chorio-decidual interface (CDi) which …

The effects of endocrine-disrupting compounds (EDCs) on the placenta, a critical gestational
organ for xenobiotic protection, are well reported; however, models to determine the role of …

The integrity of fetal membranes enables biological functions that protect the fetus and
maintain the pregnancy. Any compromise in fetal membrane function can predispose a …

Despite recent standardization of placental evaluation and establishment of criteria for
diagnosis of major patterns of placental injury, placental pathological examination remains …

Intrauterine growth restriction and prematurity determine low birth weight. The combination
of the three conditions results in different neonatal phenotypes that interfere with child …