Intracellular calcium leak in heart failure and atrial fibrillation: a unifying mechanism and therapeutic target

H Dridi, A Kushnir, R Zalk, Q Yuan, Z Melville… - Nature Reviews …, 2020 - nature.com
Ca2+ is a fundamental second messenger in all cell types and is required for numerous
essential cellular functions, including cardiac and skeletal muscle contraction. The …

The Impact of Vitamin E Supplementation on Oxidative Stress, Cognitive Functions, and Aging‐Related Gene Expression in Aged Mice

F Molavi Vasei, MY Zamanian… - Food Science & …, 2024 - Wiley Online Library
This study investigated the effects of different doses of vitamin E on oxidative stress,
cognitive function, and gene expression in aged mice. A total of 32 male mice, aged 12 …

Unnatural verticilide enantiomer inhibits type 2 ryanodine receptor-mediated calcium leak and is antiarrhythmic

SM Batiste, DJ Blackwell, K Kim… - Proceedings of the …, 2019 - National Acad Sciences
Ca2+ leak via ryanodine receptor type 2 (RyR2) can cause potentially fatal arrhythmias in a
variety of heart diseases and has also been implicated in neurodegenerative and seizure …

Targeting intracellular calcium stores alleviates neurological morbidities in a DFP-based rat model of gulf war illness

KF Phillips, E Santos, RE Blair… - Toxicological …, 2019 - academic.oup.com
Abstract Gulf War Illness (GWI) is a chronic multi-symptom disorder afflicting the veterans of
the First Gulf War, and includes neurological symptoms characterized by depression and …

Calcium hypothesis of Gulf War Illness: Role of calcium ions in neurological morbidities in a DFP-based rat model for Gulf War Illness

KF Phillips, LS Deshpande - Neuroscience Insights, 2020 - journals.sagepub.com
Gulf War Illness (GWI) refers to a multi-system disorder that afflicts approximately 30% of
First Gulf War (GW) veterans. Amongst the symptoms exhibited, mood and memory …

Long-lasting neurobehavioral alterations in burn-injured mice resembling post-traumatic stress disorder in humans

QH Zhang, JW Hao, GL Li, XJ Ji, M Zhou… - Experimental neurology, 2020 - Elsevier
Objective To establish an animal model for posttraumatic stress disorder in burn-injured
patients. Methods Thermal-injured mice with 15% total body surface area were subjected to …

AIP limits neurotransmitter release by inhibiting calcium bursts from the ryanodine receptor

B Chen, P Liu, EJ Hujber, Y Li, EM Jorgensen… - Nature …, 2017 - nature.com
Pituitary tumors are frequently associated with mutations in the AIP gene and are sometimes
associated with hypersecretion of growth hormone. It is unclear whether other factors …

The ryanodine receptor stabilizer S107 ameliorates contractility of adult Rbm20 knockout rat cardiomyocytes

W Guo, C Zhu, Z Yin, Y Zhang, C Wang… - Physiological …, 2021 - Wiley Online Library
Abstract RNA binding motif 20 (RBM20) cardiomyopathy has been detected in
approximately 3% of populations afflicted with dilated cardiomyopathy (DCM). It is well …

Distinct signatures on d‐galactose‐induced aging and preventive/protective potency of two low‐dose vitamin D supplementation regimens on working memory …

S Salemi, MY Zamanian, L Giménez‐Llort… - Food Science & …, 2023 - Wiley Online Library
Chronic administration of d‐galactose (d‐gal) in rodents reproduces the overproduction of
reactive oxygen species of physiological aging. The present research shows for the first time …

Association of FK506 binding proteins with RyR channels–effect of CLIC2 binding on sub-conductance opening and FKBP binding

SJ Richardson, GA Steele, EM Gallant… - Journal of cell …, 2017 - journals.biologists.com
ABSTRACT Ryanodine receptor (RyR) Ca2+ channels are central to striated muscle
function and influence signalling in neurons and other cell types. Beneficially low RyR …