Intracellular calcium leak in heart failure and atrial fibrillation: a unifying mechanism and therapeutic target
Ca2+ is a fundamental second messenger in all cell types and is required for numerous
essential cellular functions, including cardiac and skeletal muscle contraction. The …
essential cellular functions, including cardiac and skeletal muscle contraction. The …
The Impact of Vitamin E Supplementation on Oxidative Stress, Cognitive Functions, and Aging‐Related Gene Expression in Aged Mice
F Molavi Vasei, MY Zamanian… - Food Science & …, 2024 - Wiley Online Library
This study investigated the effects of different doses of vitamin E on oxidative stress,
cognitive function, and gene expression in aged mice. A total of 32 male mice, aged 12 …
cognitive function, and gene expression in aged mice. A total of 32 male mice, aged 12 …
Unnatural verticilide enantiomer inhibits type 2 ryanodine receptor-mediated calcium leak and is antiarrhythmic
SM Batiste, DJ Blackwell, K Kim… - Proceedings of the …, 2019 - National Acad Sciences
Ca2+ leak via ryanodine receptor type 2 (RyR2) can cause potentially fatal arrhythmias in a
variety of heart diseases and has also been implicated in neurodegenerative and seizure …
variety of heart diseases and has also been implicated in neurodegenerative and seizure …
Targeting intracellular calcium stores alleviates neurological morbidities in a DFP-based rat model of gulf war illness
KF Phillips, E Santos, RE Blair… - Toxicological …, 2019 - academic.oup.com
Abstract Gulf War Illness (GWI) is a chronic multi-symptom disorder afflicting the veterans of
the First Gulf War, and includes neurological symptoms characterized by depression and …
the First Gulf War, and includes neurological symptoms characterized by depression and …
Calcium hypothesis of Gulf War Illness: Role of calcium ions in neurological morbidities in a DFP-based rat model for Gulf War Illness
KF Phillips, LS Deshpande - Neuroscience Insights, 2020 - journals.sagepub.com
Gulf War Illness (GWI) refers to a multi-system disorder that afflicts approximately 30% of
First Gulf War (GW) veterans. Amongst the symptoms exhibited, mood and memory …
First Gulf War (GW) veterans. Amongst the symptoms exhibited, mood and memory …
Long-lasting neurobehavioral alterations in burn-injured mice resembling post-traumatic stress disorder in humans
QH Zhang, JW Hao, GL Li, XJ Ji, M Zhou… - Experimental neurology, 2020 - Elsevier
Objective To establish an animal model for posttraumatic stress disorder in burn-injured
patients. Methods Thermal-injured mice with 15% total body surface area were subjected to …
patients. Methods Thermal-injured mice with 15% total body surface area were subjected to …
AIP limits neurotransmitter release by inhibiting calcium bursts from the ryanodine receptor
Pituitary tumors are frequently associated with mutations in the AIP gene and are sometimes
associated with hypersecretion of growth hormone. It is unclear whether other factors …
associated with hypersecretion of growth hormone. It is unclear whether other factors …
The ryanodine receptor stabilizer S107 ameliorates contractility of adult Rbm20 knockout rat cardiomyocytes
Abstract RNA binding motif 20 (RBM20) cardiomyopathy has been detected in
approximately 3% of populations afflicted with dilated cardiomyopathy (DCM). It is well …
approximately 3% of populations afflicted with dilated cardiomyopathy (DCM). It is well …
Distinct signatures on d‐galactose‐induced aging and preventive/protective potency of two low‐dose vitamin D supplementation regimens on working memory …
S Salemi, MY Zamanian, L Giménez‐Llort… - Food Science & …, 2023 - Wiley Online Library
Chronic administration of d‐galactose (d‐gal) in rodents reproduces the overproduction of
reactive oxygen species of physiological aging. The present research shows for the first time …
reactive oxygen species of physiological aging. The present research shows for the first time …
Association of FK506 binding proteins with RyR channels–effect of CLIC2 binding on sub-conductance opening and FKBP binding
SJ Richardson, GA Steele, EM Gallant… - Journal of cell …, 2017 - journals.biologists.com
ABSTRACT Ryanodine receptor (RyR) Ca2+ channels are central to striated muscle
function and influence signalling in neurons and other cell types. Beneficially low RyR …
function and influence signalling in neurons and other cell types. Beneficially low RyR …