Therapies for neonatal encephalopathy: Targeting the latent, secondary and tertiary phases of evolving brain injury

AA Chakkarapani, H Aly, M Benders, CM Cotten… - Seminars in Fetal and …, 2021 - Elsevier
In term and near-term neonates with neonatal encephalopathy, therapeutic hypothermia
protocols are well established. The current focus is on how to improve outcomes further and …

[HTML][HTML] Noble gas and neuroprotection: From bench to bedside

H Yin, Z Chen, H Zhao, H Huang, W Liu - Frontiers in Pharmacology, 2022 - frontiersin.org
In recent years, inert gases such as helium, argon, and xenon have gained considerable
attention for their medical value. Noble gases present an intriguing scientific paradox …

[HTML][HTML] Treatment with inhaled Argon: a systematic review of pre-clinical and clinical studies with meta-analysis on neuroprotective effect

G Merigo, G Florio, F Madotto, A Magliocca, I Silvestri… - …, 2024 - thelancet.com
Summary Background Argon (Ar) has been proposed as a potential therapeutic agent in
multiple clinical conditions, specifically in organ protection. However, conflicting data on pre …

[HTML][HTML] Inhaled 45–50% argon augments hypothermic brain protection in a piglet model of perinatal asphyxia

KD Broad, I Fierens, B Fleiss, E Rocha-Ferreira… - Neurobiology of …, 2016 - Elsevier
Cooling to 33.5° C in babies with neonatal encephalopathy significantly reduces death and
disability, however additional therapies are needed to maximize brain protection. Following …

[HTML][HTML] Minocycline modulates microglia polarization in ischemia-reperfusion model of retinal degeneration and induces neuroprotection

A Ahmed, LL Wang, S Abdelmaksoud, A Aboelgheit… - Scientific reports, 2017 - nature.com
Retinal ischemia-reperfusion (IR) injury causes irreversible loss of neurons and ultimately
leads to permanent visual impairment and blindness. The cellular response under this …

Argon mediates protection by interleukin‐8 suppression via a TLR2/TLR4/STAT3/NF‐κB pathway in a model of apoptosis in neuroblastoma cells in vitro and following ischemia …

F Ulbrich, T Lerach, J Biermann… - Journal of …, 2016 - Wiley Online Library
Argon has recently come into scientific focus as a neuroprotective agent. The underlying
neuroprotective mechanism remains unknown although toll‐like receptors were recently …

[HTML][HTML] Argon reduces microglial activation and inflammatory cytokine expression in retinal ischemia/reperfusion injury

U Goebel, S Scheid, S Spassov… - Neural regeneration …, 2021 - journals.lww.com
We previously found that argon exerts its neuroprotective effect in part by inhibition of the toll-
like receptors (TLR) 2 and 4. The downstream transcription factors signal transducer and …

Resveratrol ameliorates retinal ischemia/reperfusion injury in C57BL/6J mice via downregulation of caspase-3

H Seong, J Ryu, WS Yoo, SJ Kim, YS Han… - Current Eye …, 2017 - Taylor & Francis
ABSTRACT Purpose: Ischemia/reperfusion (I/R) injury induces apoptosis in retinal ganglion
cells (RGCs). Resveratrol (Res) is a potent natural antioxidant with beneficial effects in many …

Positive neuroprotective effect of Argon inhalation after photochemically induced ischemic stroke model in rats

DN Silachev, EA Boeva, EI Yakupova… - Bulletin of Experimental …, 2023 - Springer
We studied the effect of 2-h inhalation of argon-oxygen mixture (Ar 70%/O2 30%) after
photochemically induced stroke and on days 2 and 3 after stroke modeling on the severity of …

[HTML][HTML] Argon preconditioning protects neuronal cells with a Toll-like receptor-mediated effect

S Scheid, A Lejarre, J Wollborn, H Buerkle… - Neural regeneration …, 2023 - journals.lww.com
The noble gas argon has the potential to protect neuronal cells from cell death. So far, this
effect has been studied in treatment after acute damage. Preconditioning using argon has …