Aptamer-based detection of circulating targets for precision medicine

L Wu, Y Wang, X Xu, Y Liu, B Lin, M Zhang… - Chemical …, 2021 - ACS Publications
The past decade has witnessed ongoing progress in precision medicine to improve human
health. As an emerging diagnostic technique, liquid biopsy can provide real-time …

Recent advances in aptamer discovery and applications

Y Zhang, BS Lai, M Juhas - Molecules, 2019 - mdpi.com
Aptamers are short, single-stranded DNA, RNA, or synthetic XNA molecules that can be
developed with high affinity and specificity to interact with any desired targets. They have …

[HTML][HTML] Aptamers used for biosensors and targeted therapy

Y Ning, J Hu, F Lu - Biomedicine & Pharmacotherapy, 2020 - Elsevier
Aptamers are single-stranded nucleic acid sequences that can bind to target molecules with
high selectivity and affinity. Most aptamers are screened in vitro by a combinatorial biology …

Aptamers in biomedicine: Selection strategies and recent advances

G Ștefan, O Hosu, K De Wael, MJ Lobo-Castañón… - Electrochimica …, 2021 - Elsevier
Aptamers have come in the spotlight as bio-mimetic molecular recognition elements in the
field of biomedicine due to various applications in diagnostics, drug delivery, therapeutics …

[HTML][HTML] Aptamer grafted nanoparticle as targeted therapeutic tool for the treatment of breast cancer

A Sheikh, S Md, P Kesharwani - Biomedicine & Pharmacotherapy, 2022 - Elsevier
Breast carcinomas repeat their number and grow exponentially making it extremely frequent
malignancy among women. Approximately, 70–80% of early diagnosed or non-metastatic …

The application of Aptamer in biomarker discovery

Y Li, WW Tam, Y Yu, Z Zhuo, Z Xue, C Tsang, X Qiao… - Biomarker …, 2023 - Springer
Biomarkers are detectable molecules that can reflect specific physiological states of cells,
organs, and organisms and therefore be regarded as indicators for specific diseases. And …

Artificial intelligence in aptamer–target binding prediction

Z Chen, L Hu, BT Zhang, A Lu, Y Wang, Y Yu… - International journal of …, 2021 - mdpi.com
Aptamers are short single-stranded DNA, RNA, or synthetic Xeno nucleic acids (XNA)
molecules that can interact with corresponding targets with high affinity. Owing to their …

Drug discovery of DKK1 inhibitors

H Jiang, Z Zhang, Y Yu, HY Chu, S Yu, S Yao… - Frontiers in …, 2022 - frontiersin.org
Dickkopf-1 (DKK1) is a well-characterized Wnt inhibitor and component of the Wnt/β-catenin
signaling pathway, whose dysregulation is associated with multiple abnormal pathologies …

[HTML][HTML] Aptamer-functionalized liposomes for drug delivery

KY Wong, MS Wong, J Liu - Biomedical journal, 2024 - Elsevier
Among the various targeting ligands for drug delivery, aptamers have attracted much interest
in recent years because of their smaller size compared to antibodies, ease of modification …

Systematic evolution of ligands by exponential enrichment technologies and aptamer-based applications: Recent progress and challenges in precision medicine of …

Y Xu, X Jiang, Y Zhou, M Ma, M Wang… - … in Bioengineering and …, 2021 - frontiersin.org
Infectious diseases are considered as a pressing challenge to global public health. Accurate
and rapid diagnostics tools for early recognition of the pathogen, as well as individualized …