Aptamer-based detection of circulating targets for precision medicine
L Wu, Y Wang, X Xu, Y Liu, B Lin, M Zhang… - Chemical …, 2021 - ACS Publications
The past decade has witnessed ongoing progress in precision medicine to improve human
health. As an emerging diagnostic technique, liquid biopsy can provide real-time …
health. As an emerging diagnostic technique, liquid biopsy can provide real-time …
Recent advances in aptamer discovery and applications
Y Zhang, BS Lai, M Juhas - Molecules, 2019 - mdpi.com
Aptamers are short, single-stranded DNA, RNA, or synthetic XNA molecules that can be
developed with high affinity and specificity to interact with any desired targets. They have …
developed with high affinity and specificity to interact with any desired targets. They have …
[HTML][HTML] Aptamers used for biosensors and targeted therapy
Y Ning, J Hu, F Lu - Biomedicine & Pharmacotherapy, 2020 - Elsevier
Aptamers are single-stranded nucleic acid sequences that can bind to target molecules with
high selectivity and affinity. Most aptamers are screened in vitro by a combinatorial biology …
high selectivity and affinity. Most aptamers are screened in vitro by a combinatorial biology …
Aptamers in biomedicine: Selection strategies and recent advances
Aptamers have come in the spotlight as bio-mimetic molecular recognition elements in the
field of biomedicine due to various applications in diagnostics, drug delivery, therapeutics …
field of biomedicine due to various applications in diagnostics, drug delivery, therapeutics …
[HTML][HTML] Aptamer grafted nanoparticle as targeted therapeutic tool for the treatment of breast cancer
Breast carcinomas repeat their number and grow exponentially making it extremely frequent
malignancy among women. Approximately, 70–80% of early diagnosed or non-metastatic …
malignancy among women. Approximately, 70–80% of early diagnosed or non-metastatic …
The application of Aptamer in biomarker discovery
Y Li, WW Tam, Y Yu, Z Zhuo, Z Xue, C Tsang, X Qiao… - Biomarker …, 2023 - Springer
Biomarkers are detectable molecules that can reflect specific physiological states of cells,
organs, and organisms and therefore be regarded as indicators for specific diseases. And …
organs, and organisms and therefore be regarded as indicators for specific diseases. And …
Artificial intelligence in aptamer–target binding prediction
Aptamers are short single-stranded DNA, RNA, or synthetic Xeno nucleic acids (XNA)
molecules that can interact with corresponding targets with high affinity. Owing to their …
molecules that can interact with corresponding targets with high affinity. Owing to their …
Drug discovery of DKK1 inhibitors
H Jiang, Z Zhang, Y Yu, HY Chu, S Yu, S Yao… - Frontiers in …, 2022 - frontiersin.org
Dickkopf-1 (DKK1) is a well-characterized Wnt inhibitor and component of the Wnt/β-catenin
signaling pathway, whose dysregulation is associated with multiple abnormal pathologies …
signaling pathway, whose dysregulation is associated with multiple abnormal pathologies …
[HTML][HTML] Aptamer-functionalized liposomes for drug delivery
Among the various targeting ligands for drug delivery, aptamers have attracted much interest
in recent years because of their smaller size compared to antibodies, ease of modification …
in recent years because of their smaller size compared to antibodies, ease of modification …
Systematic evolution of ligands by exponential enrichment technologies and aptamer-based applications: Recent progress and challenges in precision medicine of …
Y Xu, X Jiang, Y Zhou, M Ma, M Wang… - … in Bioengineering and …, 2021 - frontiersin.org
Infectious diseases are considered as a pressing challenge to global public health. Accurate
and rapid diagnostics tools for early recognition of the pathogen, as well as individualized …
and rapid diagnostics tools for early recognition of the pathogen, as well as individualized …