The signaling component of the mammalian Fibroblast Growth Factor (FGF) family is
comprised of eighteen secreted proteins that interact with four signaling tyrosine kinase FGF …

The CRISPR system is a revolutionary genome editing tool that has the potential to
revolutionize the field of cancer research and therapy. The ability to precisely target and edit …

Fibroblast growth factors (FGFs) are involved in a variety of cellular processes, such as
stemness, proliferation, anti‐apoptosis, drug resistance, and angiogenesis. Here, FGF …

Rhabdomyosarcoma (RMS), the most common soft tissue sarcoma in children, has
traditionally been classified into embryonal rhabdomyosarcoma (ERMS) and alveolar …

Rhabdomyosarcomas are malignancies associated with a rhabdomyoblastic phenotype
which can be demonstrated morphologically or by immunohistochemistry for MYOD1 and …

The fibroblast growth factor receptors (FGFRs) regulate important biological processes
including cell proliferation and differentiation during development and tissue repair. Over the …

Rare but recurrent mutations in the fibroblast growth factor receptor (FGFR) pathways, most
commonly in one of the four FGFR receptor tyrosine kinase genes, can potentially be …

Although urothelial carcinoma (UC) of the urinary bladder generally portends a favorable
prognosis, metastatic tumors often follow an aggressive clinical course. DNA was extracted …

Fibroblast growth factors (FGFs) and their receptors (FGFRs) are transmembrane growth
factor receptors with wide tissue distribution. FGF/FGFR signaling is involved in neoplastic …

FOXO proteins are a sub-group of a superfamily of forkhead box (FOX)-containing
transcription factors (TFs). FOXOs play an important role in regulating a plethora of …