Functional nucleic acid (NA)-based drugs have a broad range of applications since they
allow the alteration and control of gene/protein expression patterns in cells. In principle …

Targeted delivery by either systemic or local targeting of therapeutics to the bone is an
attractive treatment for various bone metabolism diseases such as osteoporosis …

Aptamers are short single-stranded oligonucleotides that are capable of binding various
molecules with high affinity and specificity. When the technology of aptamer selection was …

Systematic evolution of ligand by exponential enrichment (SELEX) is an efficient method
used to isolate high-affinity single stranded oligonucleotides from a large random sequence …

Currently, major concerns about the safety and efficacy of RNA interference (RNAi)-based
bone anabolic strategies still exist because of the lack of direct osteoblast-specific delivery …

Skeletal muscle disorders have posed great threats to health. Selective delivery of drugs
and oligonucleotides to skeletal muscle is challenging. Aptamers can improve targeting …

Aptamers are single-stranded DNA or RNA oligomers, identified from a random sequence
pool, with the ability to form unique and versatile tertiary structures that bind to cognate …

Functionally integrating DNA and other nucleic acids with nanoparticles in all their different
physicochemical forms has produced a rich variety of composite nanomaterials which, in …

Pancreatic cancer is a highly lethal malignancy associated with tissues of the pancreas.
Early diagnosis and effective treatment are crucial to improving the survival rate of patients …

PROteolysis TArgeting Chimeras (PROTACs) induce targeted protein degradation by
hijacking the intracellular ubiquitin proteasome system, thus emerging as a new strategy for …