K63 ubiquitination in immune signaling
C Madiraju, JP Novack, JC Reed, S Matsuzawa - Trends in Immunology, 2022 - cell.com
Ubc13-catalyzed K63 ubiquitination is a major control point for immune signaling. Recent
evidence has shown that the control of multiple immune functions, including chronic …
evidence has shown that the control of multiple immune functions, including chronic …
TRIM proteins in host defense and viral pathogenesis
Abstract Purpose of Review Tripartite motif (TRIM) proteins are a large group of E3 ubiquitin
ligases involved in different cellular functions. Of special interest are their roles in innate …
ligases involved in different cellular functions. Of special interest are their roles in innate …
Mechanism and inhibition of the papain‐like protease, PLpro, of SARS‐CoV‐2
T Klemm, G Ebert, DJ Calleja, CC Allison… - The EMBO …, 2020 - embopress.org
The SARS‐CoV‐2 coronavirus encodes an essential papain‐like protease domain as part of
its non‐structural protein (nsp)‐3, namely SARS2 PLpro, that cleaves the viral polyprotein …
its non‐structural protein (nsp)‐3, namely SARS2 PLpro, that cleaves the viral polyprotein …
Ubiquitination of SARS-CoV-2 ORF7a promotes antagonism of interferon response
Z Cao, H Xia, R Rajsbaum, X Xia, H Wang… - Cellular & molecular …, 2021 - nature.com
Understanding interactions between the host and SARS-CoV-2 is essential for developing
effective vaccines and therapeutics. Here, we report that SARS-CoV-2 usurps the host …
effective vaccines and therapeutics. Here, we report that SARS-CoV-2 usurps the host …
[HTML][HTML] Macrophage RGS12 contributes to osteoarthritis pathogenesis through enhancing the ubiquitination
G Yuan, S Yang, S Yang - Genes & Diseases, 2022 - Elsevier
Ubiquitination has important functions in osteoarthritis (OA), yet the mechanism remains
unclear. Here, we identify the regulator of G protein signaling 12 (RGS12) in macrophages …
unclear. Here, we identify the regulator of G protein signaling 12 (RGS12) in macrophages …
Gut Microbiota Dysbiosis Influences Metabolic Homeostasis in Spodoptera frugiperda
Y Chen, H Zhou, Y Lai, Q Chen, XQ Yu… - Frontiers in …, 2021 - frontiersin.org
Insect gut microbiota plays important roles in acquiring nutrition, preventing pathogens
infection, modulating immune responses, and communicating with environment. Gut …
infection, modulating immune responses, and communicating with environment. Gut …
Exploring the versatility of the covalent thiol–alkyne reaction with substituted propargyl warheads: a deciding role for the cysteine protease
Terminal unactivated alkynes are nowadays considered the golden standard for cysteine-
reactive warheads in activity-based probes (ABPs) targeting cysteine deubiquitinating …
reactive warheads in activity-based probes (ABPs) targeting cysteine deubiquitinating …
Non-proteolytic ubiquitylation in cellular signaling and human disease
Ubiquitylation is one of the most common post-translational modifications (PTMs) of proteins
that frequently targets substrates for proteasomal degradation. However it can also result in …
that frequently targets substrates for proteasomal degradation. However it can also result in …
The TRIMendous role of TRIMs in virus–host interactions
The innate antiviral response is integral in protecting the host against virus infection. Many
proteins regulate these signaling pathways including ubiquitin enzymes. The ubiquitin …
proteins regulate these signaling pathways including ubiquitin enzymes. The ubiquitin …
The RNA helicase DHX16 recognizes specific viral RNA to trigger RIG-I-dependent innate antiviral immunity
Summary Type I interferons (IFN-I) are essential to establish antiviral innate immunity.
Unanchored (or free) polyubiquitin (poly-Ub) has been shown to regulate IFN-I responses …
Unanchored (or free) polyubiquitin (poly-Ub) has been shown to regulate IFN-I responses …