The nuclear receptor superfamily: A structural perspective

ER Weikum, X Liu, EA Ortlund - Protein Science, 2018 - Wiley Online Library
Nuclear receptors (NRs) are a family of transcription factors that regulate numerous
physiological processes such as metabolism, reproduction, inflammation, as well as the …

Mechanisms of estrogen action

S Nilsson, S Makela, E Treuter… - Physiological …, 2001 - journals.physiology.org
Our appreciation of the physiological functions of estrogens and the mechanisms through
which estrogens bring about these functions has changed during the past decade. Just as …

Nuclear hormone receptors and gene expression

A Aranda, A Pascual - Physiological reviews, 2001 - journals.physiology.org
The nuclear hormone receptor superfamily includes receptors for thyroid and steroid
hormones, retinoids and vitamin D, as well as different “orphan” receptors of unknown …

The coregulator exchange in transcriptional functions of nuclear receptors

CK Glass, MG Rosenfeld - Genes & development, 2000 - genesdev.cshlp.org
Nuclear receptors (NR) comprise a family of transcription factors that regulate gene
expression in a liganddependent manner. Members of the NR superfamily include receptors …

Molecular basis for feedback regulation of bile acid synthesis by nuclear receptors

TT Lu, M Makishima, JJ Repa, K Schoonjans, TA Kerr… - Molecular cell, 2000 - cell.com
The catabolism of cholesterol into bile acids is regulated by oxysterols and bile acids, which
induce or repress transcription of the pathway's rate-limiting enzyme cholesterol 7α …

Nuclear receptor coregulators: cellular and molecular biology

NJ McKenna, RB Lanz, BW O'Malley - Endocrine reviews, 1999 - academic.oup.com
NUCLEAR receptor coregulators are coactivators or corepressors that are required by
nuclear receptors for efficient transcriptional regulation. In this context, we define …

Orphan nuclear receptors: from gene to function

V Giguère - Endocrine reviews, 1999 - academic.oup.com
II. Nuclear Receptors: General Concepts A. Anatomy of nuclear receptors B. Mechanisms of
action III. Orphan Nuclear Receptors A. Definition

Structure–function relationship of estrogen receptor α and β: Impact on human health

P Ascenzi, A Bocedi, M Marino - Molecular aspects of medicine, 2006 - Elsevier
17β-Estradiol (E2) controls many aspects of human physiology, including development,
reproduction and homeostasis, through regulation of the transcriptional activity of its cognate …

Development and function of the human fetal adrenal cortex: a key component in the feto-placental unit

H Ishimoto, RB Jaffe - Endocrine reviews, 2011 - academic.oup.com
Continuous efforts have been devoted to unraveling the biophysiology and development of
the human fetal adrenal cortex, which is structurally and functionally unique from other …

Foxl2 up-regulates aromatase gene transcription in a female-specific manner by binding to the promoter as well as interacting with ad4 binding protein/steroidogenic …

DS Wang, T Kobayashi, LY Zhou… - Molecular …, 2007 - academic.oup.com
Increasing evidence suggests the crucial role of estrogen in ovarian differentiation of
nonmammalian vertebrates including fish. The present study has investigated the plausible …