LPA receptor signaling: pharmacology, physiology, and pathophysiology
Lysophosphatidic acid (LPA) is a small ubiquitous lipid found in vertebrate and
nonvertebrate organisms that mediates diverse biological actions and demonstrates …
nonvertebrate organisms that mediates diverse biological actions and demonstrates …
Lysophospholipid receptor nomenclature review: IUPHAR Review 8
Lysophospholipids encompass a diverse range of small, membrane‐derived phospholipids
that act as extracellular signals. The signalling properties are mediated by 7 …
that act as extracellular signals. The signalling properties are mediated by 7 …
Lysophosphatidic acid signaling in the nervous system
The brain is composed of many lipids with varied forms that serve not only as structural
components but also as essential signaling molecules. Lysophosphatidic acid (LPA) is an …
components but also as essential signaling molecules. Lysophosphatidic acid (LPA) is an …
International union of basic and clinical pharmacology. LXXVIII. Lysophospholipid receptor nomenclature
Lysophospholipids are cell membrane-derived lipids that include both glycerophospholipids
such as lysophosphatidic acid (LPA) and sphingoid lipids such as sphingosine 1-phosphate …
such as lysophosphatidic acid (LPA) and sphingoid lipids such as sphingosine 1-phosphate …
Lysophospholipids and their receptors in the central nervous system
Lysophosphatidic acid (LPA) and sphingosine 1-phosphate (S1P), two of the best-studied
lysophospholipids, are known to influence diverse biological events, including organismal …
lysophospholipids, are known to influence diverse biological events, including organismal …
The novel perspectives of adipokines on brain health
First seen as a fat-storage tissue, the adipose tissue is considered as a critical player in the
endocrine system. Precisely, adipose tissue can produce an array of bioactive factors …
endocrine system. Precisely, adipose tissue can produce an array of bioactive factors …
Lysophosphatidic acid, a simple phospholipid with myriad functions
K Yanagida, T Shimizu - Pharmacology & Therapeutics, 2023 - Elsevier
Lysophosphatidic acid (LPA) is a simple phospholipid consisting of a phosphate group,
glycerol moiety, and only one hydrocarbon chain. Despite its simple chemical structure, LPA …
glycerol moiety, and only one hydrocarbon chain. Despite its simple chemical structure, LPA …
Insights into the pharmacological relevance of lysophospholipid receptors
T Mutoh, R Rivera, J Chun - British journal of pharmacology, 2012 - Wiley Online Library
The discovery of lysophospholipid (LP) 7‐transmembrane, G protein‐coupled receptors
(GPCRs) that began in the 1990s, together with research into the functional roles of the …
(GPCRs) that began in the 1990s, together with research into the functional roles of the …
Activation of lysophosphatidic acid receptor type 1 contributes to pathophysiology of spinal cord injury
E Santos-Nogueira, C López-Serrano… - Journal of …, 2015 - Soc Neuroscience
Lysophosphatidic acid (LPA) is an extracellular lipid mediator involved in many
physiological functions that signals through six known G-protein-coupled receptors (LPA1 …
physiological functions that signals through six known G-protein-coupled receptors (LPA1 …
Anxiety-like behavior and microglial activation in the amygdala after acute neuroinflammation induced by microbial neuraminidase
A León-Rodríguez, MM Fernández-Arjona… - Scientific Reports, 2022 - nature.com
Short-term behavioral alterations are associated with infection and aid the recovery from
sickness. However, concerns have raised that sustained behavioral disturbances after acute …
sickness. However, concerns have raised that sustained behavioral disturbances after acute …