LPA receptor signaling: pharmacology, physiology, and pathophysiology

YC Yung, NC Stoddard, J Chun - Journal of lipid research, 2014 - ASBMB
Lysophosphatidic acid (LPA) is a small ubiquitous lipid found in vertebrate and
nonvertebrate organisms that mediates diverse biological actions and demonstrates …

Lysophospholipid receptor nomenclature review: IUPHAR Review 8

Y Kihara, M Maceyka, S Spiegel… - British journal of …, 2014 - Wiley Online Library
Lysophospholipids encompass a diverse range of small, membrane‐derived phospholipids
that act as extracellular signals. The signalling properties are mediated by 7 …

Lysophosphatidic acid signaling in the nervous system

YC Yung, NC Stoddard, H Mirendil, J Chun - Neuron, 2015 - cell.com
The brain is composed of many lipids with varied forms that serve not only as structural
components but also as essential signaling molecules. Lysophosphatidic acid (LPA) is an …

International union of basic and clinical pharmacology. LXXVIII. Lysophospholipid receptor nomenclature

J Chun, T Hla, KR Lynch, S Spiegel… - Pharmacological …, 2010 - ASPET
Lysophospholipids are cell membrane-derived lipids that include both glycerophospholipids
such as lysophosphatidic acid (LPA) and sphingoid lipids such as sphingosine 1-phosphate …

Lysophospholipids and their receptors in the central nervous system

JW Choi, J Chun - Biochimica et Biophysica Acta (BBA)-Molecular and …, 2013 - Elsevier
Lysophosphatidic acid (LPA) and sphingosine 1-phosphate (S1P), two of the best-studied
lysophospholipids, are known to influence diverse biological events, including organismal …

The novel perspectives of adipokines on brain health

TH Lee, KK Cheng, RL Hoo, PM Siu, S Yau - International journal of …, 2019 - mdpi.com
First seen as a fat-storage tissue, the adipose tissue is considered as a critical player in the
endocrine system. Precisely, adipose tissue can produce an array of bioactive factors …

Lysophosphatidic acid, a simple phospholipid with myriad functions

K Yanagida, T Shimizu - Pharmacology & Therapeutics, 2023 - Elsevier
Lysophosphatidic acid (LPA) is a simple phospholipid consisting of a phosphate group,
glycerol moiety, and only one hydrocarbon chain. Despite its simple chemical structure, LPA …

Insights into the pharmacological relevance of lysophospholipid receptors

T Mutoh, R Rivera, J Chun - British journal of pharmacology, 2012 - Wiley Online Library
The discovery of lysophospholipid (LP) 7‐transmembrane, G protein‐coupled receptors
(GPCRs) that began in the 1990s, together with research into the functional roles of the …

Activation of lysophosphatidic acid receptor type 1 contributes to pathophysiology of spinal cord injury

E Santos-Nogueira, C López-Serrano… - Journal of …, 2015 - Soc Neuroscience
Lysophosphatidic acid (LPA) is an extracellular lipid mediator involved in many
physiological functions that signals through six known G-protein-coupled receptors (LPA1 …

Anxiety-like behavior and microglial activation in the amygdala after acute neuroinflammation induced by microbial neuraminidase

A León-Rodríguez, MM Fernández-Arjona… - Scientific Reports, 2022 - nature.com
Short-term behavioral alterations are associated with infection and aid the recovery from
sickness. However, concerns have raised that sustained behavioral disturbances after acute …