Vascular remodeling is the adaptive response to various physiological and
pathophysiological alterations that are closely related to aging and vascular diseases …

Cartilage oligomeric matrix protein (COMP) is an extracellular matrix (ECM) glycoprotein that
is critical for collagen assembly and ECM stability. Mutations of COMP cause endoplasmic …

Compelling evidence indicates that epigenetic regulations orchestrate dynamic macrophage
polarization. N 6-methyladenosine (m6A) methylation is the most abundant epigenetic …

Macrophage polarization plays a crucial role in regulating abdominal aortic aneurysm (AAA)
formation. Circular RNAs (circRNAs) are important regulators of macrophage polarization …

Background: The metalloprotease ADAMTS-7 (a disintegrin and metalloproteinase with
thrombospondin type 1 motif 7) is a novel locus associated with human coronary …

Vascular grafts often exhibit low patency rates in clinical settings due to the pathological
environment within the patients requiring the surgery. Mesenchymal stem cell (MSC) …

Background Identifying effective drugs to suppress vascular inflammation is a promising
strategy to delay the progression of abdominal aortic aneurysm (AAA). Itaconate has a vital …

Background Aortic dissection is a severe inflammatory vascular disease with high mortality
and limited therapeutic options. The hallmarks of aortic dissection comprise aortic …

Vascular calcification (VC) is one of the major causes of cardiovascular morbidity and
mortality in patients with chronic kidney disease (CKD). VC is a complex process expressing …

Objectives The aim of this study was to identify biomarkers for radiographic OA severity and
progression acting within the inflammation and metabolic pathways. Methods For 3517 …