Homocysteine excess: delineating the possible mechanism of neurotoxicity and depression

P Bhatia, N Singh - Fundamental & clinical pharmacology, 2015 - Wiley Online Library
Homocysteine (Hcy) is a nonproteogenic sulfur containing amino acid derived from dietary
methionine through demethylation. Homocysteine can be re‐methylated to methionine …

[PDF][PDF] Hyperhomocysteinemia as a risk factor for the neuronal system disorders

M Petras, Z Tatarkova, M Kovalska, D Mokra… - J Physiol …, 2014 - academia.edu
Elevated concentration of the homocysteine (Hcy) in human tissues, resulting either from
mutations in genes enconding Hcy-metabolizing enzymes, or from deficiences of folic acid …

Effectiveness of N-acetylcysteine in autism spectrum disorders: A meta-analysis of randomized controlled trials

TM Lee, KM Lee, CY Lee, HC Lee… - Australian & New …, 2021 - journals.sagepub.com
Objective: Currently, pharmaceutical treatment options for autism spectrum disorder are
limited. Brain glutaminergic dysregulation is observed in autism spectrum disorder. N …

Stressor-induced NMDAR dysfunction as a unifying hypothesis for the aetiology, pathogenesis and comorbidity of clinical depression

WN Marsden - Medical hypotheses, 2011 - Elsevier
Typically the monoamine system has been the central focus of neurobiological research into
depression and represents the major target of modern antidepressant medications; although …

Rivastigmine reverses the decrease in synapsin and memory caused by homocysteine: is there relation to inflammation?

OV Ramires Junior, TM Dos Santos, JS Silveira… - Molecular …, 2022 - Springer
Elevated levels of homocysteine (Hcy) in the blood, called hyperhomocysteinemia (HHcy), is
a prevalent risk factor for it has been shown that Hcy induces oxidative stress and increases …

Association of induced hyperhomocysteinemia with Alzheimer's disease-like neurodegeneration in rat cortical neurons after global ischemia-reperfusion injury

M Kovalska, B Tothova, L Kovalska, Z Tatarkova… - Neurochemical …, 2018 - Springer
Alzheimer's disease (AD) is a progressive and irreversible neurodegenerative disorder that
results in massive hippocampal and neocortical neuronal loss leading to dementia and …

Physical exercise reverses glutamate uptake and oxidative stress effects of chronic homocysteine administration in the rat

MJ da Cunha, AA da Cunha, AGK Ferreira… - International journal of …, 2012 - Elsevier
The influence of physical exercise on the effects elicited by homocysteine on glutamate
uptake and some parameters of oxidative stress, namely thiobarbituric acid-reactive …

Homocysteine and cerebral atrophy: the epidemiology of dementia in Singapore study

B Tan, N Venketasubramanian… - Journal of …, 2018 - content.iospress.com
Background: Plasma homocysteine levels are increasingly studied as a potential risk factor
for dementia. Elevated homocysteine levels have been linked with gray and white matter …

Homocysteine alters glutamate uptake and Na+,K+-ATPase activity and oxidative status in rats hippocampus: protection by vitamin C

FR Machado, AGK Ferreira, AA da Cunha… - Metabolic brain …, 2011 - Springer
In the present study we investigate the effect of homocysteine on glutamate uptake, Na+, K+-
ATPase, enzymatic antioxidant defenses, as well as reactive species levels in hippocampus …

Cortical lobar volume reductions associated with homocysteine-related subcortical brain atrophy and poorer cognition in healthy aging

H Song, PK Bharadwaj, DA Raichlen… - Frontiers in Aging …, 2024 - frontiersin.org
Homocysteine (Hcy) is a cardiovascular risk factor implicated in cognitive impairment and
cerebrovascular disease but has also been associated with Alzheimer's disease. In 160 …