Custom microfluidic chip design enables cost-effective three-dimensional spatiotemporal transcriptomics with a wide field of view

J Zhu, K Pang, B Hu, R He, N Wang, Z Jiang, P Ji… - Nature Genetics, 2024 - nature.com
Spatial transcriptomic techniques offer unprecedented insights into the molecular
organization of complex tissues. However, integrating cost-effectiveness, high throughput, a …

Deciphering normal and cancer stem cell niches by spatial transcriptomics: opportunities and challenges

H Sarkar, E Lee, SL Lopez-Darwin… - Genes & …, 2024 - genesdev.cshlp.org
Cancer stem cells (CSCs) often exhibit stem-like attributes that depend on an intricate
stemness-promoting cellular ecosystem within their niche. The interplay between CSCs and …

Mapping Cell Atlases at the Single‐Cell Level

F Ye, J Wang, J Li, Y Mei, G Guo - Advanced Science, 2024 - Wiley Online Library
Recent advancements in single‐cell technologies have led to rapid developments in the
construction of cell atlases. These atlases have the potential to provide detailed information …

Reconstructing axial progenitor field dynamics in mouse stem cell-derived embryoids

A Bolondi, BK Law, H Kretzmer, SI Gassaloglu… - Developmental cell, 2024 - cell.com
Embryogenesis requires substantial coordination to translate genetic programs to the
collective behavior of differentiating cells, but understanding how cellular decisions control …

Thyroid hormone action during GABAergic neuron maturation: The quest for mechanisms

S Richard, J Ren, F Flamant - Frontiers in Endocrinology, 2023 - frontiersin.org
Thyroid hormone (TH) signaling plays a major role in mammalian brain development. Data
obtained in the past years in animal models have pinpointed GABAergic neurons as a major …

SpatialQC: automated quality control for spatial transcriptome data

G Mao, Y Yang, Z Luo, C Lin, P Xie - Bioinformatics, 2024 - academic.oup.com
The advent of spatial transcriptomics has revolutionized our understanding of the spatial
heterogeneity in tissues, providing unprecedented insights into the cellular and molecular …

SCAN: Spatiotemporal Cloud Atlas for Neural cells

Y Deng, Y Lu, M Li, J Shen, S Qin… - Nucleic Acids …, 2024 - academic.oup.com
The nervous system is one of the most complicated and enigmatic systems within the animal
kingdom. Recently, the emergence and development of spatial transcriptomics (ST) and …

Whole-embryo spatial transcriptomics at subcellular resolution from gastrulation to organogenesis

Y Wan, J El Kholtei, I Jenie, M Colomer-Rosell, J Liu… - BioRxiv, 2024 - biorxiv.org
Spatiotemporal patterns of gene expression underlie embryogenesis. Despite progress in
single-cell genomics, mapping these patterns across whole embryos with comprehensive …

Leveraging spatial multiomics to unravel tissue architecture in embryo development

F Jiang, H Wang, Z Li, G Cui, G Peng - Trends in Genetics, 2024 - cell.com
Spatial multiomics technologies have revolutionized biomedical research by enabling the
simultaneous measurement of multiple omics modalities within intact tissue sections. This …

Genetics of Mayer-Rokitansky-Küster-Hauser (MRKH) syndrome: advancements and implications

MK Herlin - Frontiers in Endocrinology, 2024 - frontiersin.org
Mayer-Rokitansky-Küster-Hauser (MRKH) syndrome is a congenital anomaly characterized
by agenesis/aplasia of the uterus and upper part of the vagina in females with normal …