Custom microfluidic chip design enables cost-effective three-dimensional spatiotemporal transcriptomics with a wide field of view
Spatial transcriptomic techniques offer unprecedented insights into the molecular
organization of complex tissues. However, integrating cost-effectiveness, high throughput, a …
organization of complex tissues. However, integrating cost-effectiveness, high throughput, a …
Deciphering normal and cancer stem cell niches by spatial transcriptomics: opportunities and challenges
H Sarkar, E Lee, SL Lopez-Darwin… - Genes & …, 2024 - genesdev.cshlp.org
Cancer stem cells (CSCs) often exhibit stem-like attributes that depend on an intricate
stemness-promoting cellular ecosystem within their niche. The interplay between CSCs and …
stemness-promoting cellular ecosystem within their niche. The interplay between CSCs and …
Mapping Cell Atlases at the Single‐Cell Level
Recent advancements in single‐cell technologies have led to rapid developments in the
construction of cell atlases. These atlases have the potential to provide detailed information …
construction of cell atlases. These atlases have the potential to provide detailed information …
Reconstructing axial progenitor field dynamics in mouse stem cell-derived embryoids
Embryogenesis requires substantial coordination to translate genetic programs to the
collective behavior of differentiating cells, but understanding how cellular decisions control …
collective behavior of differentiating cells, but understanding how cellular decisions control …
Thyroid hormone action during GABAergic neuron maturation: The quest for mechanisms
S Richard, J Ren, F Flamant - Frontiers in Endocrinology, 2023 - frontiersin.org
Thyroid hormone (TH) signaling plays a major role in mammalian brain development. Data
obtained in the past years in animal models have pinpointed GABAergic neurons as a major …
obtained in the past years in animal models have pinpointed GABAergic neurons as a major …
SpatialQC: automated quality control for spatial transcriptome data
G Mao, Y Yang, Z Luo, C Lin, P Xie - Bioinformatics, 2024 - academic.oup.com
The advent of spatial transcriptomics has revolutionized our understanding of the spatial
heterogeneity in tissues, providing unprecedented insights into the cellular and molecular …
heterogeneity in tissues, providing unprecedented insights into the cellular and molecular …
SCAN: Spatiotemporal Cloud Atlas for Neural cells
Y Deng, Y Lu, M Li, J Shen, S Qin… - Nucleic Acids …, 2024 - academic.oup.com
The nervous system is one of the most complicated and enigmatic systems within the animal
kingdom. Recently, the emergence and development of spatial transcriptomics (ST) and …
kingdom. Recently, the emergence and development of spatial transcriptomics (ST) and …
Whole-embryo spatial transcriptomics at subcellular resolution from gastrulation to organogenesis
Spatiotemporal patterns of gene expression underlie embryogenesis. Despite progress in
single-cell genomics, mapping these patterns across whole embryos with comprehensive …
single-cell genomics, mapping these patterns across whole embryos with comprehensive …
Leveraging spatial multiomics to unravel tissue architecture in embryo development
F Jiang, H Wang, Z Li, G Cui, G Peng - Trends in Genetics, 2024 - cell.com
Spatial multiomics technologies have revolutionized biomedical research by enabling the
simultaneous measurement of multiple omics modalities within intact tissue sections. This …
simultaneous measurement of multiple omics modalities within intact tissue sections. This …
Genetics of Mayer-Rokitansky-Küster-Hauser (MRKH) syndrome: advancements and implications
MK Herlin - Frontiers in Endocrinology, 2024 - frontiersin.org
Mayer-Rokitansky-Küster-Hauser (MRKH) syndrome is a congenital anomaly characterized
by agenesis/aplasia of the uterus and upper part of the vagina in females with normal …
by agenesis/aplasia of the uterus and upper part of the vagina in females with normal …