Neutrophils in the pathogenesis of rheumatoid arthritis and systemic lupus erythematosus: same foe different MO

M Fresneda Alarcon, Z McLaren, HL Wright - Frontiers in immunology, 2021 - frontiersin.org
Dysregulated neutrophil activation contributes to the pathogenesis of autoimmune diseases
including rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE). Neutrophil …

Systemic lupus erythematosus and cardiovascular disease

J Frostegård - Journal of Internal Medicine, 2023 - Wiley Online Library
The prognosis in systemic lupus erythematosus (SLE) has improved due to better treatment
and care, but cardiovascular disease (CVD) still remains an important clinical problem, since …

Phase 1 double-blind randomized safety trial of the Janus kinase inhibitor tofacitinib in systemic lupus erythematosus

SA Hasni, S Gupta, M Davis, E Poncio… - Nature …, 2021 - nature.com
Increased risk of premature cardiovascular disease (CVD) is well recognized in systemic
lupus erythematosus (SLE). Aberrant type I-Interferon (IFN)-neutrophil interactions contribute …

Cardiovascular disease in systemic lupus erythematosus: an update

Y Liu, MJ Kaplan - Current opinion in rheumatology, 2018 - journals.lww.com
Recent discoveries have further strengthened the critical role of SLE-related immune
dysregulation and metabolic disturbances in promoting accelerated CVD. Understanding …

[HTML][HTML] Neutrophil subsets and their gene signature associate with vascular inflammation and coronary atherosclerosis in lupus

PM Carlucci, MM Purmalek, AK Dey… - JCI insight, 2018 - ncbi.nlm.nih.gov
BACKGROUND. Systemic lupus erythematosus (SLE) is associated with enhanced risk of
atherosclerotic cardiovascular disease not explained by Framingham risk score (FRS) …

Lipid metabolism: immune regulation and therapeutic prospectives in systemic lupus erythematosus

W Sun, P Li, J Cai, J Ma, X Zhang, Y Song… - Frontiers in …, 2022 - frontiersin.org
Systemic lupus erythematosus (SLE) is a heterogeneous disease characterized by the
production of abnormal autoantibodies and immune complexes that can affect the organ and …

Cardiovascular disease risk and pathogenesis in systemic lupus erythematosus

CB Oliveira, MJ Kaplan - Seminars in immunopathology, 2022 - Springer
Systemic lupus erythematosus (SLE) often features extensive cardiovascular (CV)
comorbidity and patients with SLE are at significantly increased risk of CV event occurrence …

Endothelial function and endothelial progenitor cells in systemic lupus erythematosus

A Mak, JKY Chan - Nature Reviews Rheumatology, 2022 - nature.com
The observations that traditional cardiovascular disease (CVD) risk factors fail to fully
account for the excessive cardiovascular mortality in patients with systemic lupus …

Mechanistic insight into premature atherosclerosis and cardiovascular complications in systemic lupus erythematosus

Y Liu, X Yu, W Zhang, X Zhang, M Wang, F Ji - Journal of Autoimmunity, 2022 - Elsevier
Systemic lupus erythematosus (SLE) is associated with a significant risk of cardiovascular
disease (CVD), which substantially increases disease mortality and morbidity. The overall …

Replenishing HDL with synthetic HDL has multiple protective effects against sepsis in mice

L Guo, EE Morin, M Yu, L Mei, MV Fawaz, Q Wang… - Science …, 2022 - science.org
Sepsis is a major health issue with mortality exceeding 30% and few treatment options. We
found that high-density lipoprotein cholesterol (HDL-C) abundance was reduced by 45% in …