Optimal energy production is required for oocyte and embryo development, and
mitochondrial abnormalities have devastating reproductive consequences. Improvement of …

Highly precise micromanipulation tools that can manipulate and interrogate cell organelles
and components must be developed to support the rapid development of new cell-based …

Mitochondrial DNA (mtDNA) mutations are maternally inherited and are associated with a
broad range of debilitating and fatal diseases. Reproductive technologies designed to …

Options for the effective treatment of hereditary optic neuropathies have been a long time
coming. The successful launch of the antioxidant idebenone for Leber's Hereditary Optic …

Mitochondrial disorders comprise a molecular and clinically diverse group of diseases that
are associated with mitochondrial dysfunction leading to multi-organ disease. With recent …

Two leading European professional societies, the European Society of Human Genetics and
the European Society for Human Reproduction and Embryology, have worked together …

Human mitochondria produce ATP and metabolites to support development and maintain
cellular homeostasis. Mitochondria harbor multiple copies of a maternally inherited, non …

Summary mtDNA sequence alterations are challenging to generate but desirable for basic
studies and potential correction of mtDNA diseases. Here, we report a new method for …

Highlights•During ART treatment, gametes and embryos are exposed to non-physiological
processes.•The short-and long-term safety of assisted reproduction is of concern.•There is …

Assisted reproductive technology (ART) refers to processing gametes in vitro and usually
involves in vitro fertilization. Originally developed for the treatment of infertility, culture of …