Pilocytic astrocytomas (PAs) were recognized as a discrete clinical entity over 70 years ago.
They are relatively benign (WHO grade I) and have, as a group, a 10-year survival of over …

Both solid tumours and leukaemias show considerable histological and functional
heterogeneity. It is widely accepted that genetic lesions have a major role in determining …

DNA methylation is essential for normal development,, and has been implicated in many
pathologies including cancer,. Our knowledge about the genome-wide distribution of DNA …

Brain tumors are the most common solid tumors of childhood, and pilocytic astrocytomas
(PA) are the most common central nervous system tumor in 5 to 19 year olds. Little is known …

Purpose Long-term survival for children with diffuse intrinsic pontine glioma (DIPG) is less
than 10%, and new therapeutic targets are urgently required. We evaluated a large cohort of …

The molecular pathogenesis of pediatric astrocytomas is still poorly understood. To further
understand the genetic abnormalities associated with these tumors, we performed a …

For the past decade, it has been recognized that pediatric low-grade gliomas (LGGs) and
glial-neuronal tumors carry distinct molecular alterations with resultant aberrant intracellular …

Diffuse intrinsic pontine glioma (DIPG) is one of the most frequent malignant pediatric brain
tumor and its prognosis is universaly fatal. No significant improvement has been made in …

Childhood tumors containing cells that are morphologically and functionally similar to
normal progenitor cells provide fertile ground for investigating the links between …

Diffuse gliomas such as astrocytomas and oligodendrogliomas are the most common form of
intrinsic brain tumor in adults. Even within a single pathologic class, these tumors are both …